Hassane Mchaourab Archives
Study explores how bacteria become drug resistant
Jan. 6, 2022—Vanderbilt researchers have revealed more of the inner-workings of a two-stage “molecular motor” in the cell membrane that enables bacteria to become resistant to drugs.
Study details regulation of a multi-drug transporter
May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
New trans-institutional program to focus on genetic variations, disease
May. 9, 2019—A new program at Vanderbilt will help researchers determine more precisely how genetic variations contribute to disease and what potentially can be done to put them right.
Cellular stress defense
Oct. 12, 2018—The modular architecture of small heat-shock proteins contributes to the ability of these proteins to aid cells in responding to stress.
Fueling the MATE transporter
Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
Faculty meeting recognizes excellence in education, research and clinical service
May. 24, 2018—During Wednesday’s Spring Faculty Meeting, Jeff Balser, M.D., Ph.D., dean of Vanderbilt University School of Medicine and President and CEO of Vanderbilt University Medical Center, highlighted the medical school’s rising stature among the country’s top-tier institutions.
A cataract-heart connection
Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.
Study catches ‘notorious’ drug pump in action
Mar. 16, 2017—Researchers at Vanderbilt University Medical Center (VUMC) have mapped the conformational changes that occur in a protein “notorious” for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system.
Membrane fats impact drug transporter
Jul. 14, 2016—New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it.
Dynamics of a drug resistance transporter
Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.
In a zebrafish’s eye
Jul. 29, 2015—Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.
New view of transporter dynamics
Oct. 23, 2014—New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.
