A new view of a cholesterol carrier
Feb. 7, 2023—Vanderbilt researchers developed a novel method to measure small RNAs carried by HDL and demonstrated that these molecules circulate in greater concentrations than previously believed and are likely to contribute to communication between immune cells.
Study suggests new mechanism for lipid transporter
Sep. 15, 2022—A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought.
Potential protection from atherosclerosis
Aug. 19, 2021—Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.
NIH grant bolsters research on heart disease, cholesterol
Jan. 21, 2021—Thanks to major funding from the National Institutes of Health (NIH), researchers at Vanderbilt University Medical Center have made major inroads in understanding how high-density lipoprotein (HDL), commonly known as good cholesterol, in some cases may actually contribute to the development of atherosclerosis.
A new contributor to atherosclerosis
Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.
HDL-cholesterol and breast cancer risk
Jan. 23, 2020—Genetic analyses suggest that high circulating HDL-cholesterol levels may increase breast cancer risk — a surprising finding since increased HDL-cholesterol is thought to be healthy.
Obesity negates beneficial drug effects
Nov. 8, 2018—A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.
Scavengers “protect” HDL
Jun. 29, 2018—Jun. 29, 2018—Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease.
Understanding HDL structure
May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.
HDL and kidney injury after surgery
Jan. 17, 2018—Higher concentrations of high-density lipoproteins — HDL, the “good” cholesterol — may be protective against acute kidney injury after cardiac surgery, Vanderbilt researchers have discovered.
Kidney disease impacts HDL function
Feb. 11, 2015—Chronic kidney disease impairs the protective functions of HDL, Vanderbilt researchers report this month.
Major grant spurs deeper look into ‘good cholesterol’
Aug. 21, 2014—In some cases, HDL, the "good cholesterol," may not function properly and may actually accelerate atherosclerosis.