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HDL Archives

Potential protection from atherosclerosis

Aug. 19, 2021—Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.

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NIH grant bolsters research on heart disease, cholesterol

Jan. 21, 2021—Thanks to major funding from the National Institutes of Health (NIH), researchers at Vanderbilt University Medical Center have made major inroads in understanding how high-density lipoprotein (HDL), commonly known as good cholesterol, in some cases may actually contribute to the development of atherosclerosis.

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A new contributor to atherosclerosis

Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

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HDL-cholesterol and breast cancer risk

Jan. 23, 2020—Genetic analyses suggest that high circulating HDL-cholesterol levels may increase breast cancer risk — a surprising finding since increased HDL-cholesterol is thought to be healthy.

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Obesity negates beneficial drug effects

Nov. 8, 2018—A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.

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Scavengers “protect” HDL

Jun. 29, 2018—Jun. 29, 2018—Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease.

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Understanding HDL structure

May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.

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HDL and kidney injury after surgery

Jan. 17, 2018—Higher concentrations of high-density lipoproteins — HDL, the “good” cholesterol — may be protective against acute kidney injury after cardiac surgery, Vanderbilt researchers have discovered.

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Kidney disease impacts HDL function

Feb. 11, 2015—Chronic kidney disease impairs the protective functions of HDL, Vanderbilt researchers report this month.

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Major grant spurs deeper look into ‘good cholesterol’

Aug. 21, 2014—In some cases, HDL, the "good cholesterol," may not function properly and may actually accelerate atherosclerosis.

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HDL cholesterol impaired in kidney disease

Jan. 21, 2013—HDL cholesterol is impaired in patients with chronic kidney disease – and may increase their cardiovascular disease risk.

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Gene’s impact on ‘good’ cholesterol could affect heart disease risk

Jul. 12, 2012—A genetic variant may help keep an individual’s “good” cholesterol in check.

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