infection Archives
Novel drugs have potential for treating tuberculosis
Apr. 24, 2023—Drug-resistant tuberculosis is on the rise, and novel antibacterial drugs called SPTs have potential for treating the deadly lung infection.
Study reveals new genetic disorder that causes susceptibility to opportunistic infections
Jan. 20, 2023—An international consortium co-led by Vanderbilt's Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia.
Vascular dysfunction during sepsis
Oct. 25, 2022—Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.
Molecular imaging of C. diff infection
Sep. 30, 2021—C. difficile — the leading cause of hospital-associated intestinal infections — induces a rapid influx of bile acids into the gut, which could provide a novel target for blocking infection.
Transporter’s role in gut barrier
Apr. 16, 2020—A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.
Imaging host-pathogen battle for metal
Oct. 31, 2019—An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.
Fetal membranes and microbial threats
Oct. 26, 2018—Understanding how cells communicate in the membranes surrounding the developing fetus could suggest new strategies for preventing infections, premature birth and adverse pregnancy outcomes.
Putting the brakes on sepsis
May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.
Lighting up iron levels
Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.
Excess dietary manganese increases risk of staph infection in heart
Sep. 21, 2017—Too much dietary manganese — an essential trace mineral found in leafy green vegetables, fruits and nuts — promotes infection of the heart by the bacterium Staphylococcus aureus (“staph”).
Predicting the infection response
Apr. 19, 2017—Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.
Immune defenses in asthma
Apr. 5, 2016—Vanderbilt researchers show that a certain factor negatively impacts the first-line responder cells in the lungs, providing one explanation for why patients with asthma are at greater risk for invasive bacterial disease.