insulin Archives
CaMKII enhances insulin secretion
May. 14, 2014—The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.
Channel drug restores glucose balance
Apr. 16, 2014—A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.
Matrix remodeling and insulin resistance
Apr. 10, 2014—The extracellular matrix that surrounds cells plays a role in the development of insulin resistance.
Is healthy obesity possible?
Jan. 29, 2014—It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity.
Searching for beta cell stimulators
Jan. 13, 2014—Vanderbilt researchers describe a new technique for identifying factors that stimulate the proliferation of pancreatic beta cells – factors that might offer therapeutic options for diabetes.
Relaxin combats insulin resistance
Oct. 16, 2013—The hormone relaxin may offer a novel approach for treating diet-induced insulin resistance.
‘Yo-yo dieting’ inflames fat tissue
Aug. 9, 2013—Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone.
Matrix member key to insulin resistance
Jun. 6, 2013—A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target.
“Silent” B cells trigger autoimmunity
Apr. 3, 2013—Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.
Discovery Lecture explores brain’s sensitivity to insulin
Feb. 28, 2013—Diabetes has a big impact on the brain.
Pumping up the pancreas in pregnancy
Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.
