Skip to main content

intestines Archives

Nutrient absorption disease model

Feb. 2, 2023—Vanderbilt researchers developed a model of a patient-specific mutation to explore the pathology of microvillus inclusion disease, a genetic disorder that causes life-threatening diarrhea.

Read more


Motor protein linked to intestinal cell differentiation

Aug. 5, 2021—The motor protein MYO5B, a cause of the congenital intestinal disorder microvillus inclusion disease, does more than move cellular cargo, Vanderbilt researchers have discovered.

Read more


Probiotic protection

Mar. 4, 2021—A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease.

Read more


Microvilli in motion

Sep. 19, 2019—Live cell imaging studies have revealed that microvilli — finger-like protrusions on the surface of epithelial cells — move and collide as they form the brush border.

Read more


Host-microbe interactions in the gut

Aug. 13, 2019—Vanderbilt investigators demonstrated that intestinal cells promote beneficial microbe behavior — the findings support developing microbiota-based therapies for intestinal health.

Read more


Intestinal immune cell interactions

Jul. 30, 2019—Understanding the roles of various immune cells that reside in the gut lining could shed light on inflammatory bowel diseases.

Read more


Adhesion protein optimizes border

Feb. 14, 2019—Matthew Tyska and colleagues have found that an adhesion protein plays a key role in building the intestinal brush border that is essential for absorbing nutrients.

Read more


How microvilli form

Sep. 13, 2018—A protein called IRTKS helps build the microvilli that form the border of cells in the intestines, explaining why the protein is a frequent target of gut pathogens.

Read more


Cell skeleton and the brush border

Jan. 31, 2018—Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines.

Read more


Lineage tracing in the gut

Nov. 30, 2017—Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop.

Read more


Gut response to fluid flow

Oct. 26, 2017—Vanderbilt researchers have discovered that microvilli – finger-like projections from cells in the intestine – respond to the shear stress of fluid flow to drive a cellular pathway that regulates nutrient balance.

Read more


Motoring to the tips of the brush border

Oct. 6, 2016—New findings implicate a motor protein in the assembly of the brush border in the intestines and kidneys – a specialized surface that is critical for healthy organ function.

Read more


Recent Stories from VUMC News and Communications Publications

Vanderbilt Medicine
Hope
Momentum
VUMC Voice

more