Journal of Immunology Archives

Tracking lung macrophages

May. 4, 2023—A new technique will allow researchers to track subsets of immune cells that patrol and defend the lungs, to better understand the roles of these cells during lung inflammation, infection and injury.

Impaired neutrophils in autoimmunity

Jan. 27, 2022—Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity.

3d rendering white blood cells with red blood cells

A new regulator of B cell development

Oct. 8, 2019—New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells.

Novel infection fighter

Jun. 13, 2018—A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.

Disease-fighting antibody production

Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.

chess player knocking over opponents king

Predicting the infection response

Apr. 19, 2017—Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.

Pathology of septic shock

Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.

Restore T cells to fight leukemia

Sep. 14, 2016—Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.

“Silent” B cells trigger autoimmunity

Apr. 3, 2013—Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.

Target for inflammatory bowel disease

Mar. 1, 2013—The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments.