Journal of Immunology Archives
Impaired neutrophils in autoimmunity
Jan. 27, 2022—Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity.
A new regulator of B cell development
Oct. 8, 2019—New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells.
Novel infection fighter
Jun. 13, 2018—A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.
Disease-fighting antibody production
Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.
Predicting the infection response
Apr. 19, 2017—Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.
Pathology of septic shock
Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.
Restore T cells to fight leukemia
Sep. 14, 2016—Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.
“Silent” B cells trigger autoimmunity
Apr. 3, 2013—Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.
Target for inflammatory bowel disease
Mar. 1, 2013—The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments.
Low oxygen could protect sick kidneys
Jun. 28, 2012—Low oxygen – and the activation of factors that respond to this situation – may be protective in chronic kidney disease.