journal publication Archives
Pumping up the pancreas in pregnancy
Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.
Obesity genes linked to uterine cancer
Jan. 20, 2012—In addition to body mass index, genetic markers of obesity may provide value in predicting endometrial cancer risk.
Fishing for heart attack repair tools
Jan. 5, 2012—Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool: zebrafish. The researchers visually screened...
Clues to flattened faces
Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...
Meds’ benefits differ in dialysis patients
Jan. 5, 2012—About half of kidney patients will die from heart disease within five years of starting dialysis, yet patients with kidney failure are rarely included in heart disease research. Jorge Gamboa, M.D., T. Alp Ikizler, M.D., and Nancy Brown, M.D., completed a small study that suggests a more personalized approach to selecting medication for heart disease...
Green tea totals colorectal cancer
Jan. 5, 2012—Tea and its phytochemical constituents have demonstrated anti-cancer properties in cell and animal experiments – particularly green tea, which has higher levels of antioxidant polyphenols than other types of tea. Gong Yang, M.D., MPH, and colleagues evaluated the association between green tea consumption and colorectal cancer risk in participants of the Shanghai Men’s Health Study....
