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kidney Archives

The role of integrins in kidney “integrity”

Jan. 13, 2022—Receptors called integrins play a critical role in maintaining the structure of the kidney, Vanderbilt researchers have discovered.

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Harrison Society researcher discovers key regulator of kidney cell structure

Nov. 4, 2021—New research from Vanderbilt could aid efforts to promote kidney regeneration after injury or to develop engineered organs.

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New insights into kidney development

Apr. 15, 2021—Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function.

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VUMC, UCSF win KidneyX award for implantable home dialysis system

Jul. 22, 2020—A $500,000 KidneyX prize has been awarded to The Kidney Project — a collaboration between Vanderbilt University Medical Center and University of California, San Francisco (UCSF) — for the development of an implantable dialysis system that would enable patients to safely and effectively treat kidney failure at home.

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Implant one day may replace dialysis

May. 18, 2020—Vanderbilt researchers used pharmacological manipulations to increase salt and water transport by kidney cells grown in culture, a step necessary for realizing an implantable artificial kidney device.

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Vanderbilt investigators lead effort to create map of the human kidney

Oct. 31, 2019—Short of mandating universal diabetes treatment, regular exercise and low-calorie diets, little can be done to stem the rising tide of kidney failure — unless scientists can figure out why exactly the kidney’s filtration units, the glomeruli, stop working.

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YAP after acute kidney injury

Aug. 16, 2018—Activation of the signaling protein YAP may be a target for treating acute kidney injury, which affects up to 20 percent of hospitalized patients.

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Kidney disease imaging

Mar. 22, 2018—Making multiple measurements with MRI can provide comprehensive information about the molecular and cellular changes caused by kidney injury.

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Cell skeleton and the brush border

Jan. 31, 2018—Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines.

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Motoring to the tips of the brush border

Oct. 6, 2016—New findings implicate a motor protein in the assembly of the brush border in the intestines and kidneys – a specialized surface that is critical for healthy organ function.

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Immune system a must for kidney repair

Nov. 12, 2015—A signaling protein that is essential for recovery from acute kidney injury works by increasing the population of tissue-repairing immune cells.

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VUMC receives NIH grant to develop artificial kidney

Nov. 3, 2015—The National Institutes of Health has awarded a four-year, $6 million grant to investigators at Vanderbilt University Medical Center (VUMC) and the University of California at San Francisco (UCSF) to develop an implantable artificial kidney.

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