Martin Egli Archives
Grant enhances study of new chemotherapy targets
Oct. 18, 2018—Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.
Altered metabolism and disease
Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.
Faulty building blocks in DNA
Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.
Bypassing DNA damage
May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
Carcinogenic chemicals cramp DNA
Nov. 21, 2012—Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.
DNA: From modification to mutation
Jun. 8, 2012—Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.
Fungus toxin gets in the way in DNA
Oct. 7, 2011—Structural studies are providing insight to how aflatoxin – a toxin produced by fungi – contributes to cancer development.
Fluorine aids gene silencing
Feb. 15, 2011—Modifying a form of RNAs may improve their efficacy for research and medical uses.
