metabolism Archives
Study may lead to new diabetes, heart disease treatments
Jan. 12, 2023—Vanderbilt research found that deletion of an autophagy-participating factor named PIK3C3 from the fat cells of mice led to compromised body temperature control, abnormal blood lipid levels, fatty liver and diabetes.
Codeine metabolizer status in clinical practice
Apr. 5, 2021—Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine.
Blocking tumor ‘signals’ and ‘fuel’
Aug. 25, 2020—Combining two drugs reduced colorectal cancer cell growth in vitro and in an animal model, suggesting the combination may be a promising treatment for patients.
A dual-purpose metabolic switch
May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.
Transporter mutation alters cell energy
Feb. 20, 2020—A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.
New look at atherosclerosis
Jul. 11, 2019—A new imaging method makes it possible to directly measure cell division and changes in metabolism in atherosclerotic plaques.
Steroid binding to metabolic enzyme
Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.
A spicy finding
Jan. 16, 2018—Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.
Altered metabolism and disease
Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.
Links between immune cells and metabolism explored
Nov. 10, 2016—At the intersection of immunology and metabolism is a burgeoning new field: immunometabolism. It’s an area where Vanderbilt has exceptional strengths, said Jeffrey Rathmell, Ph.D., Cornelius Vanderbilt Professor of Immunobiology.
Restore T cells to fight leukemia
Sep. 14, 2016—Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.
Switching breast cancer off
Apr. 14, 2016—Signaling by a receptor that is overexpressed in aggressive forms of breast cancer has been linked to glutamine metabolism, suggesting new anti-cancer therapeutic targets.
