Reduced exercise capacity in ICU survivors
Sep. 22, 2022—ICU survivors who have impaired exercise capacity months after discharge may have damaged muscle mitochondria — the energy powerhouses of the cell, Vanderbilt researchers propose.
Mitochondria and retinal degeneration
Aug. 15, 2022—Vanderbilt researchers have developed a new cellular model for exploring mitochondrial dysfunction in age-related macular degeneration, the leading cause of blindness in people over 65.
Mitochondrial stress and hypertension
Jan. 12, 2021—Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.
Assembling cell power plant machinery
Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.
Transporter mutation alters cell energy
Feb. 20, 2020—A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.
Novel genetic study sheds new light on risk of heart attack
Oct. 11, 2018—Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.
Mitochondrial mutations and disease
Feb. 22, 2018—New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.
Study sheds light on a ‘guardian’ protein of brain function
Feb. 19, 2015—Mitochondria not only are the cell’s main power producers, they are also the chief cooks and bottle washers.
Biomarker for diabetic eye disease
Sep. 26, 2014—A person’s mitochondrial gene “signature” could predict risk for diabetic retinopathy and guide early intervention strategies.
Mitochondrial mutations not random
Nov. 25, 2013—A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues.
Model for MADD mitochondrial disease
Jul. 11, 2013—A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches.
Kids’ cells okay after mom’s cancer radiation
Jun. 22, 2012—Study finds no evidence of increased mitochondrial mutations in the children of women treated with radiation for cancer.