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Molecular Physiology & Biophysics Archives

Histamine circuits in brain reward center

Oct. 29, 2020—Histamine — commonly associated with allergies — also has a signaling role in the brain’s reward center and may offer a novel target for treating addiction.

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Brain blood vessel response to hypoxia

Oct. 15, 2020—The brain’s response to low oxygen — growth and remodeling of blood vessels — involves certain cell types and molecular pathways, Vanderbilt researchers have discovered.

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Salt, immune cells and hypertension

Aug. 20, 2020—Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption.

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Single mutation causes seizure disorder

Jun. 22, 2020—A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

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Transporter’s role in gut barrier

Apr. 16, 2020—A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.

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Blocking stress-induced relapse

Mar. 19, 2020—Danny Winder and colleagues are teasing apart the actions of neurotransmitter receptors in a brain region linked to anxiety and addiction, with a goal of finding treatments for substance use disorders.

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Protein interactions and brain function

Feb. 20, 2020—Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory.

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Transporter mutation alters cell energy

Feb. 20, 2020—A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.

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A key to calcium signaling

Feb. 11, 2020—Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.

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Reversing stress-related anxiety

Dec. 20, 2019—Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders.

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Protein dynamics in the beating heart

Dec. 16, 2019—To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.

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Blueprint for treating epilepsy

Nov. 14, 2019—Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders.

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