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Nature Communications Archives

‘Scavenger’ molecule may point to new atherosclerosis treatment

Aug. 20, 2020—A small-molecule “scavenger” that reduces inflammation and formation of atherosclerotic plaque in blood vessels in mice potentially could lead to a new approach for treating atherosclerosis in humans, according to researchers at Vanderbilt University Medical Center.

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Cellular antiviral defenses

Jul. 23, 2020—A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

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Recurrent UTIs linked to hidden reservoir

Jul. 9, 2020—Bacterial invasion of vaginal cells sets up a protective niche and a reservoir for recurrent urinary tract infections, Vanderbilt researchers demonstrated.

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Study reveals an inherited origin of prostate cancer in families

Mar. 23, 2020—Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the study of prostate cancer patients with family histories of the disease.

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VUMC study sheds light on gastric cancer development

Jan. 16, 2020—VUMC researchers have created the world’s first laboratory model of precancerous changes in the lining of the stomach, a scientific tour de force that is helping to unlock the mysteries of gastric cancer development.

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Study shines light on architecture of kidney disease

Sep. 25, 2019—A study of 280,000 U.S. veterans, including 56,000 African Americans, has identified in greater detail than ever before the genetic architecture of kidney function and chronic kidney disease (CKD), according to researchers at Vanderbilt University Medical Center and their colleagues.

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Cellular engines of wound repair have distinct roles

Aug. 8, 2019—Vanderbilt investigators have discovered that, in contrast to prevailing dogma, fibroblasts are not all alike; instead, they have distinctive functions following tissue injury.

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Rehab technique may boost supply of donor lungs

May. 9, 2019—A new regeneration technique could potentionally add to a limited supply of donor organs for an increasing population with end-stage lung disease.

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Researchers putting the brakes on lethal childhood cancer

May. 3, 2019—Malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers. Although rare — about 20 to 25 new cases are diagnosed annually in the United States — there is no standard effective treatment for the disease, which is driven by loss of an anti-cancer protein called SNF5. The chances are very small that a child will survive a year after MRT diagnosis.

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Exploring the brain’s white matter

Mar. 14, 2019—New comprehensive functional MRI measurements point to the need to update models for assessing brain white matter activity and physiology.

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The exocyst dynamo

Dec. 13, 2018—New methods have revealed details of vesicle trafficking in cells and are applicable to any protein complexes, potentially revolutionizing our understanding of cell dynamics.

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RNA processing and antiviral immunity

Dec. 13, 2018—John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.

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