Nature Genetics Archives
New tool to probe genetic mechanisms of disease
Oct. 22, 2020—Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.
Hundreds of new blood pressure gene variations discovered
Dec. 31, 2018— by Bill Snyder In one of the largest studies of its kind, an international research team led by 20 Vanderbilt University scientists has discovered more than 200 new genetic variations associated with high blood pressure. The study, published December 21 by the journal Nature Genetics, also identified specific tissues where blood pressure genes exert...
Vanderbilt study links gene expression, disease association data
Jul. 26, 2018—An international team of researchers has integrated gene expression and disease association data to better understand the biological mechanisms of complex human diseases.
Team identifies new gene candidates for breast cancer risk
Jun. 28, 2018—Jun. 28, 2018—An international coalition led by scientists at Vanderbilt University Medical Center and the QIMR Berghofer Medical Research Institute in Herston, Australia, has identified 48 candidate susceptibility genes for breast cancer risk, including 14 genes at loci (chromosome regions) not yet reported for breast cancer.
Metastatic pancreatic cancer ‘reprograms’ for malignancy
Jan. 19, 2017—Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.
Study in East Asians identifies genes tied to colon cancer risk
Aug. 21, 2014—Colorectal cancer is one of the leading causes of death among populations around the world. While diet, physical activity and other lifestyle factors can influence the risk of developing the disease, hereditary factors also play an important role.
Gene study focuses on breast cancer in East Asian women
Jul. 24, 2014—A new study in East Asian women has identified three genetic changes linked to an increased risk of breast cancer. The research, led by Vanderbilt University investigators, was published online this week in Nature Genetics.
BMI gene study expands to people of African ancestry
Apr. 18, 2013—An international team of scientists, including six from Vanderbilt University, has identified the first unique genetic determinants of body mass index (BMI) in people of African ancestry.
Eye disorder’s genetic risk factors come into focus
Mar. 7, 2013—An international group of investigators has identified seven new genetic regions associated with age-related macular degeneration (AMD), a common cause of blindness in older individuals.