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Nature Medicine Archives

Drug trial shows reduced abnormal bone formation in those with fibrodysplasia ossificans progressiva

Sep. 28, 2023—A Vanderbilt clinical trial evaluating the investigational drug garetosmab has shown that it reduced soft-tissue flare-ups significantly and prevented new areas of abnormal bone formation in patients with fibrodysplasia ossificans progressiva.

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Rett syndrome drug studied at Vanderbilt approved for patients

Jul. 7, 2023—The first drug to treat the symptoms of Rett syndrome was recently approved, following a Nature Medicine study publishing results from the pivotal phase 3 LAVENDER study led by investigators from Vanderbilt University Medical Center to evaluate efficacy and safety of trofinetide.

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Counting steps can reduce disease risk: study

Oct. 10, 2022—A Vanderbilt study found that using a wearable activity tracker to count and increase the number and intensity of steps taken daily can reduce the risk of several common, chronic diseases.

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Two VUMC papers named among genomic medicine’s top 10

Dec. 16, 2021—Vanderbilt researchers wrote two of the “top 10” papers representing key advances in genomic medicine published between September 2020 and August 2021.

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Predictive model identifies patients for genetic testing

Jun. 3, 2021—Patients who, perhaps unbeknownst to their health care providers, are in need of genetic testing for rare undiagnosed diseases can be identified en masse based on routine information in electronic health records (EHRs), a research team reported June 3 in the journal Nature Medicine.

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Monoclonal antibody “cocktail” blocks COVID-19 variants: study

Mar. 4, 2021—A monoclonal antibody “cocktail” developed at Vanderbilt University Medical Center to neutralize the COVID-19 virus is effective against all known strains, or variants, of the virus, according to a report published today in the journal Nature Medicine.

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Antibody research at Vanderbilt University Medical Center shows promise in fight against COVID-19

Jul. 15, 2020—Based on positive results in preclinical studies reported today, potently neutralizing antibodies identified by researchers at Vanderbilt University Medical Center are showing promise as a potential therapy for preventing and treating COVID-19.

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Human lungs rejected for transplant recovered using novel technique

Jul. 13, 2020—A multidisciplinary team from Vanderbilt University Medical Center and Columbia University has demonstrated that injured human donor lungs declined for transplant can be recovered by cross-circulation between the human lung and a xenogeneic host.

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Target trials support drug safety in pregnant patients

May. 27, 2020—Out of concern for fetal safety, pregnant people have typically been excluded from drug trials. And when human health is on the line, drug studies assessing fetal safety in animal models may be viewed as far from definitive.

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Vanderbilt-led team discovers new genetic disease and defines underlying mechanism

Jan. 13, 2020—An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

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Encephalitis identified as rare toxicity of immunotherapy treatment

Jul. 22, 2019—Researchers are chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies.

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Genetic characteristics of peripheral artery disease studied

Jul. 18, 2019—New study explores why some people with peripheral artery disease present with problems with their legs, some with their heart and some with strokes.

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