NCATS Archives
Damage, disruption, delirium
Apr. 20, 2020—New findings suggest that treatments that decrease oxidative damage might help with postoperative delirium that occurs in up to 30% of cardiac surgery patients.
Transporter’s role in gut barrier
Apr. 16, 2020—A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.
Race, hormones and diabetes risk
Mar. 19, 2020—Variation in the levels of hormones called natriuretic peptides may contribute to racial differences in susceptibility to diabetes, suggesting that this hormone system may be a target for reducing risk of the disease.
Imaging breast cancer cell size
Feb. 10, 2020—A noninvasive MRI approach assesses breast tumor cell size and could be a useful way to evaluate early response to neoadjuvant therapy.
Protein dynamics in the beating heart
Dec. 16, 2019—To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.
Getting the goods on obesity
Nov. 19, 2019—Obesity and two post-operative complications linked with it have associated genetic variants in common, suggesting that obesity may be the culprit.
RSV transmission in the Middle East
Nov. 14, 2019—Understanding how RSV is transmitted, which strains dominate and how new strains emerge around the globe will guide better vaccine and anti-viral drug design.
A new regulator of B cell development
Oct. 8, 2019—New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells.
Study: personalized decision support affects intensive care
Oct. 3, 2019—For patients in pediatric intensive care who are at high risk for acute kidney injury (AKI), giving clinicians automated decision support during the electronic order entry process increased the rate of blood testing for AKI by 9%.
Treating C. diff: new purpose for an old drug?
Sep. 24, 2019—An inexpensive generic drug once used to prevent gastrointestinal ulcers in people taking daily NSAIDs protects against C. diff infection in mice.
Early detection of schizophrenia
Jun. 24, 2019—Inhibited temperament — a tendency to respond to novelty with wariness, fear or caution — may be a risk factor for schizophrenia that could be targeted for preventative interventions.
Cardiac dysfunction in DMD
Mar. 28, 2019—The protein MMP7 is elevated in blood from patients with Duchenne muscular dystrophy who have cardiac dysfunction, suggesting that it may be a biomarker for heart disease severity.
