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NCATS Archives

Genetics and blood pressure

May. 19, 2022—Including polygenic risk scores for blood pressure may improve predictive models to identify people at risk for treatment-resistant hypertension.

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Gene variants and transplant drug dose

May. 9, 2022—Genotyping multiple enzymes that metabolize the immunosuppressive drug tacrolimus — common used for lung transplant recipients — is important for correct dosing of the drug, Vanderbilt researchers found.

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Gene network linked to Type 2 diabetes

May. 5, 2022—Vanderbilt researchers used a novel analytical approach to identify a network of genes associated with Type 2 diabetes, including 31 genes that had not previously been associated with the disease.

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Peptides promote AFib arrhythmia

Apr. 11, 2022—Peptide oligomers have detrimental metabolic effects and cause pro-arrhythmic electrophysiological changes in heart atria, suggesting they may contribute to atrial fibrillation.

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New prognosis predictor and target for gastric cancer

Apr. 7, 2022—The protein CGA — a subunit of glycoprotein hormones — is a biomarker that predicts chemoresistance in gastric cancer and could be targeted along with EGFR to restore chemosensitivity.

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Rheumatoid arthritis: special deliveries

Mar. 28, 2022—Birth outcomes including postpartum infection and blood transfusion were similar in women with and without rheumatoid arthritis, and continued use of disease-modifying antirheumatic drugs and biologics is recommended to limit steroid exposure.

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Reducing obesity-related inflammation

Mar. 24, 2022—A treatment that increases levels of lipid signaling molecules reduced adipose tissue inflammation in obese adults, suggesting this pathway may be a valuable target for modulating fat and systemic inflammation.

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High blood pressure genes improve heart surgery survival in children

Mar. 24, 2022—Vanderbilt researchers have found that children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery.

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Improving care for gynecologic cancer

Mar. 15, 2022—To reduce risk of deep vein thrombosis in patients being treated for gynecologic cancer, Vanderbilt researchers recommend that providers use Khorana scores and provide prophylactic treatment according to clinical guidelines.

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Microbiome reflects COVID-19 severity

Mar. 14, 2022—Characterization of the upper respiratory tract microbiome could help predict outcomes for COVID-19 infection, Vanderbilt researchers have discovered.

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New insights into hypothalamic obesity

Feb. 10, 2022—A common Type 2 diabetes treatment being tested for hypothalamic obesity had unexpected results on weight loss and total energy expenditure, Vanderbilt researchers report.

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White matter and psychosis

Jan. 27, 2022—The microstructure of white matter in the brain could be an important risk marker for psychosis, Vanderbilt researchers have discovered.

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