NCATS Archives
COVID alters respiratory microbiota
Apr. 25, 2023—COVID-19 infection alters the microbes of the upper respiratory tract for at least several weeks, and such disturbances could impact disease severity and be targets for therapeutic interventions.
Overactive bladder and anxiety
Apr. 20, 2023—Anxiety and psychological stress impact hypersensitivity mechanisms in women that could contribute to overactive bladder — a frequent and sudden urge to urinate that is difficult to control.
Genetics and chronic pain
Apr. 20, 2023—Polygenic risk scores — scores that reflect the influence of common genetic variants — could be used to predict the likelihood of developing chronic overlapping pain conditions and guide biomarker and targeted prevention efforts.
Treating delirium detected in the ED
Mar. 7, 2023—Higher intensity physical or occupational therapy may be a useful intervention to shorten delirium duration in older hospitalized adults, Vanderbilt researchers recently reported.
Diabetes drug may improve asthma
Feb. 21, 2023—New biomarker finding strengthens the case for using GLP-1R agonists to treat patients with Type 2 diabetes who also suffer from asthma.
Early effects of Huntington disease
Jan. 6, 2023—Impairments in brain executive function happen earlier than motor symptoms in people with the gene mutation that causes Huntington disease, suggesting younger ages and cognitive symptoms be considered for any future clinical trials.
Risk score for muscular dystrophy
Nov. 22, 2022—An imaging-based risk score can identify patients with Duchenne muscular dystrophy who are at greater risk of early mortality, allowing more intensive treatment and potentially prolonging life.
Study supports removing race from estimate of kidney function
Nov. 17, 2022—An in-depth analysis by Vanderbilt investigators of published research studies supports removing race from the calculation of estimated glomerular filtration rate (eGFR) — an assessment of kidney function.
Alzheimer’s risk factor and cognition
Nov. 8, 2022—Vanderbilt researchers found that a protein with roles in innate immunity worsens memory at baseline in carriers of APOE-e4, the strongest genetic risk factor for Alzheimer’s disease, further implicating neuroinflammation in cognitive decline.
Gene mutations impair gut barrier
Nov. 7, 2022—Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.
Policy, resources crucial for lung cancer screening: study
Sep. 29, 2022—Vanderbilt reseach shows that resources for lung cancer screening programs increased the number of veterans screened.
Gender differences with bladder pain
Sep. 26, 2022—Gender differences in the pain experiences and treatment needs of people with a urologic pain syndrome could be used to improve interventions, Vanderbilt researchers report.
