NCATS Archives
‘Stretched’ cells promote cancer
Feb. 19, 2015—Mechanical stress appears to be a critical factor in activating normal tissue-associated fibroblasts to generate cancer-associated fibroblasts.
New clue to a devastating disease
Jan. 28, 2015—New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease.
New view of dopamine heteromers
Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.
Inner ear keeps bones strong
Jan. 14, 2015—Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel.
Cognitive changes in ‘standing’ syndrome
Jan. 13, 2015—Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals.
Does fish oil help prevent A-fib?
Jan. 9, 2015—Growing evidence suggests that fish oil, thought to directly prevent inflammation, oxidative stress and heart disease, may have limited clinical utility.
Atrial disease and hypertension links
Dec. 18, 2014—New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease.
Target for atherosclerosis therapies
Dec. 17, 2014—A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression.
Vanderbilt’s neurovascular chip project moves into new phase
Nov. 18, 2014—Vanderbilt researchers will play a key role in the second phase of the federal "tissue chip for drug screening" program.
Overactive stress response in obesity
Nov. 7, 2014—An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.
Biomarker for diabetic eye disease
Sep. 26, 2014—A person’s mitochondrial gene “signature” could predict risk for diabetic retinopathy and guide early intervention strategies.
A path to sarcoidosis treatment
Sep. 25, 2014—Vanderbilt investigators identify a new therapeutic target for the inflammatory lung disease sarcoidosis.
