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NCATS Archives

Sorting patient messages automatically

Dec. 20, 2017—Automated techniques can assist in understanding and managing growing volumes of messages sent through secure patient portals, Vanderbilt researchers found.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Salt, inflammation and hypertension

Nov. 13, 2017—Vanderbilt researchers have identified a pathway that links excess sodium, inflammation and hypertension.

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Impulsivity in Parkinson’s Disease

Oct. 27, 2017—A noninvasive MRI technique may help predict a troubling side effect of common medications for Parkinson’s Disease and improve clinical treatment plans.

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Gut response to fluid flow

Oct. 26, 2017—Vanderbilt researchers have discovered that microvilli – finger-like projections from cells in the intestine – respond to the shear stress of fluid flow to drive a cellular pathway that regulates nutrient balance.

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Calcium intake and colorectal cancer

Oct. 18, 2017—Calcium intake appears to protect against colorectal cancer in individuals with certain gene variants, Vanderbilt researchers have discovered.

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Delirium, benzos and the pediatric ICU

Oct. 2, 2017—With other risk factors held equal, children who received a benzodiazepine sedative drug were nearly three times more likely to experience delirium – confused thought – the following day.

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Goal of new tissue-chip research is to assess efficacy of novel epilepsy drugs

Sep. 20, 2017—An interdisciplinary team of Vanderbilt University researchers has received a two-year, $2-million federal grant to develop an “organ-on-chip” model for two genetic forms of epilepsy.

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NSAIDs, genetics and miscarriage

Sep. 20, 2017—A certain genetic variant, in combination with the use of anti-inflammatory drugs like aspirin and ibuprofen during early pregnancy, may protect women from miscarriage.

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HDAC3 role in B-cell development

Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

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Drivers of breast cancer metastasis

Jul. 20, 2017—Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported.

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NOTCH1 role in heart development

Jul. 3, 2017—The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

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