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NCI Archives

Surgery for hereditary breast cancer

Nov. 17, 2022—Similar rates of bilateral mastectomy in women with inherited mutations in high- and moderate-penetrance genes raises concerns about possible overtreatment of some patients, Vanderbilt researchers report.

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A marker for mortality

Nov. 17, 2022—A urine biomarker of inflammation was associated with increased mortality and multiple lifestyle factors, suggesting that modifications could help reduce premature mortality.

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Metabolic signatures of Type 2 diabetes risk

Oct. 24, 2022—Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.

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Aging beta cells hasten Type 2 diabetes

Oct. 20, 2022—Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

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Nerve cells and cancer progression

Sep. 22, 2022—Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.

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Cancer registries and sarcoma research

Sep. 13, 2022—The number of sarcoma research studies that use the two largest U.S. cancer registries is increasing, but over one-third of studies that asked the same research question reported conflicting findings.

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Blood cancer progression

Aug. 29, 2022—Vanderbilt researchers used single-cell technologies to explore the accumulation of mutations during blood cancer progression, which could help identify strategies for preventing leukemia before it occurs.

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Vanderbilt researchers discover how gut inflammation leads to bone loss

Aug. 25, 2022—Gastrointestinal inflammation, such as occurs in inflammatory bowel disease, triggers the expansion of a population of “bone-eating” cells, leading to bone loss.

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Study describes how E. coli co-opts cells, causes recurrent UTIs

Aug. 25, 2022—Researchers at Vanderbilt University Medical Center have discovered why the uropathogenic bacterium E. coli, the leading cause of urinary tract infections, is so tenacious; their findings could lead to new ways to prevent recurrent UTIs.

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Nanoparticles boost anti-cancer immunity

Aug. 16, 2022—An ingenious targeted nanoparticle approach developed by Vanderbilt researchers reduced tumor burden in a model of ovarian cancer.

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H. pylori and lung cancer

Aug. 1, 2022—Specific biomarkers for H. pylori — a bacterium that infects the stomach — were associated with increased risk of lung cancer, Vanderbilt researchers have discovered.

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Probing the tumor microenvironment

Jul. 12, 2022—Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

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