NEI Archives
Insights on diabetic retinopathy
Jan. 23, 2020—A drug that targets multiple pathogenic steps in diabetic retinopathy may be an ideal therapeutic strategy for the disease, Vanderbilt researchers report.
Potassium balance and glaucoma
Jul. 15, 2019—Vanderbilt Eye Institute researchers have discovered that an imbalance in the ionic environment of retinal ganglion cells may contribute to functional impairments in glaucoma.
The arrestin-GPCR connection
Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.
Novel methods to treat glaucoma
Nov. 8, 2018—Increasing a certain signaling molecule prevents the degeneration of retinal cells that are lost in glaucoma, suggesting a new way to treat this disease.
Cellular stress defense
Oct. 12, 2018—The modular architecture of small heat-shock proteins contributes to the ability of these proteins to aid cells in responding to stress.
Aqueous humor, microRNAs and glaucoma
Apr. 10, 2018—New findings highlight microRNAs — molecules that regulate gene expression — that are differentially expressed in glaucoma and could be candidate biomarkers or targets for therapy.
A cataract-heart connection
Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.
Cytokine linked to blindness
Jun. 30, 2017—A signaling molecule called interleukin-6 may be a therapeutic target to prevent vision loss or nerve degeneration in glaucoma, Vanderbilt researchers have discovered.
Protecting the blood-brain barrier
Dec. 9, 2016—Vanderbilt investigators have discovered how a promising cancer immunotherapy causes brain swelling, findings that could lead to ways to protect brain function while fighting cancers.
Imaging probe for retinal disease
Oct. 12, 2016—An imaging probe developed at Vanderbilt detects retinal inflammation early and may allow therapeutic intervention to prevent blindness.
In a zebrafish’s eye
Jul. 29, 2015—Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.
A “CRISPR” way to study disease
Jun. 11, 2015—Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.
