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Neurobiology of Disease Archives

Gene tied to childhood epilepsy

Oct. 6, 2022—Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.

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Astrocytes and epilepsy

Sep. 9, 2019—A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report.

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Novel methods to treat glaucoma

Nov. 8, 2018—Increasing a certain signaling molecule prevents the degeneration of retinal cells that are lost in glaucoma, suggesting a new way to treat this disease.

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Dementia linked to diet

Feb. 7, 2017—Some memory deficits observed in Alzheimer’s disease may be due to co-morbid illnesses – not the disease itself – and may be reversed by lifestyle changes or pharmacologic interventions.

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Copper toxicity and Parkinson’s

Feb. 5, 2015—A genetic predisposition to Parkinson’s disease makes neurons more vulnerable to the toxicity of heavy metals such as copper.

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Seizure mutation impairs receptor

Sep. 30, 2014—Defects in the production of certain receptors are linked to the pathogenesis of genetic epilepsies and fever-induced seizures.

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Neuronal clues to cholesterol-defect disorder

Apr. 20, 2012—Antioxidants may be a beneficial treatment for an inherited genetic disorder.

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Treatment window for genetic disorder

Feb. 1, 2012—Treatment with a drug used to prevent organ rejection partially reverses the course of tuberous sclerosis, research in mice suggests.

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