Neurobiology of Disease Archives
Gene tied to childhood epilepsy
Oct. 6, 2022—Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.
Astrocytes and epilepsy
Sep. 9, 2019—A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report.
Novel methods to treat glaucoma
Nov. 8, 2018—Increasing a certain signaling molecule prevents the degeneration of retinal cells that are lost in glaucoma, suggesting a new way to treat this disease.
Dementia linked to diet
Feb. 7, 2017—Some memory deficits observed in Alzheimer’s disease may be due to co-morbid illnesses – not the disease itself – and may be reversed by lifestyle changes or pharmacologic interventions.
Copper toxicity and Parkinson’s
Feb. 5, 2015—A genetic predisposition to Parkinson’s disease makes neurons more vulnerable to the toxicity of heavy metals such as copper.
Seizure mutation impairs receptor
Sep. 30, 2014—Defects in the production of certain receptors are linked to the pathogenesis of genetic epilepsies and fever-induced seizures.
Neuronal clues to cholesterol-defect disorder
Apr. 20, 2012—Antioxidants may be a beneficial treatment for an inherited genetic disorder.
Treatment window for genetic disorder
Feb. 1, 2012—Treatment with a drug used to prevent organ rejection partially reverses the course of tuberous sclerosis, research in mice suggests.
