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neurodegeneration Archives

Breaking bad with Huntington’s disease

Oct. 5, 2021—Illegal activities are a significant clinical problem in individuals with Huntington’s disease, highlighting the need for improved screening measures and protocols to guide patient management.

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New neurodegeneration culprit

Jun. 17, 2021—A young woman with a puzzling neurological illness and novel genetic variant pointed investigators to a role for dysregulated protein kinase D1 in neurodegeneration.

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Study finds that regulatory protein prevents signaling that triggers cell death

May. 6, 2021—A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

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Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease

Jul. 20, 2020—Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

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The yin and yang of cell signaling

Feb. 14, 2019—Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.

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Enzyme helps build motor that drives neuron death

Aug. 23, 2018—Vanderbilt scientists have discovered a signaling mechanism that tells neurons to die, findings that could lead to new treatments for neurodegenerative diseases.

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New culprit in nerve degeneration

Aug. 12, 2016—Vanderbilt researchers have discovered that regulation of cell volume plays a role in nerve degeneration and peripheral neuropathies.

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Insights on lysosomal storage diseases

May. 14, 2015—A novel mechanism could point to new therapies for a group of inherited diseases that share pathological features.

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Retinal neuron survival in glaucoma

Dec. 16, 2014—Understanding how the protein TRPV1 helps neurons survive after glaucoma-related stressors could lead to new therapeutic strategies for glaucoma and other neurodegenerative conditions.

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New tools to probe manganese biology

Nov. 26, 2014—Vanderbilt researchers have developed tools to probe the role of the essential metal manganese in neurons, and which offer a started point for developing therapeutic agents for manganese-related neurological disorders.

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Protein interaction protects against neurodegeneration

Sep. 2, 2014—Two proteins interact to maintain selenium levels in the brain, and protect neurons from degeneration.

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Protein boosts retinal neuron survival

Mar. 14, 2014—An ion channel protein called TRIPV1 helps retinal neurons survive the elevated eye pressure associated with glaucoma.

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