NHLBI Archives
Risk score for muscular dystrophy
Nov. 22, 2022—An imaging-based risk score can identify patients with Duchenne muscular dystrophy who are at greater risk of early mortality, allowing more intensive treatment and potentially prolonging life.
Alzheimer’s risk factor and cognition
Nov. 8, 2022—Vanderbilt researchers found that a protein with roles in innate immunity worsens memory at baseline in carriers of APOE-e4, the strongest genetic risk factor for Alzheimer’s disease, further implicating neuroinflammation in cognitive decline.
Metabolic signatures of Type 2 diabetes risk
Oct. 24, 2022—Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.
New target for lung fibrosis
Oct. 20, 2022—Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.
Skin pigment affects oxygen monitor
Oct. 11, 2022—Black patients in the ICU were more likely to have low or high blood oxygen levels than white patients, even when a pulse oximeter indicated 92-96% oxygen saturation, Vanderbilt researchers found.
Policy, resources crucial for lung cancer screening: study
Sep. 29, 2022—Vanderbilt reseach shows that resources for lung cancer screening programs increased the number of veterans screened.
Reduced exercise capacity in ICU survivors
Sep. 22, 2022—ICU survivors who have impaired exercise capacity months after discharge may have damaged muscle mitochondria — the energy powerhouses of the cell, Vanderbilt researchers propose.
Study suggests new mechanism for lipid transporter
Sep. 15, 2022—A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought.
VUMC leads effort to map heart disease-causing genetic variations
Sep. 13, 2022—Researchers from Vanderbilt University Medical Center, Stanford Medicine, the University of Toronto and Brigham and Women’s Hospital in Boston have joined forces to “map” the specific variations in more than 25 key cardiac disease genes that negatively affect heart function.
PheWAS reveals post-COVID-19 diagnoses
Sep. 8, 2022—Using a high-throughput informatics technique and electronic health records, Vanderbilt researchers found that COVID-19 survivors had an increased risk for more than 40 new diagnoses.
A new mechanism for lupus
Aug. 30, 2022—Vanderbilt researchers describe a new mechanism for the most common form of lupus and suggest a new treatment approach to this autoimmune disease.
Blood cancer progression
Aug. 29, 2022—Vanderbilt researchers used single-cell technologies to explore the accumulation of mutations during blood cancer progression, which could help identify strategies for preventing leukemia before it occurs.
