NHLBI Archives
Boosting cell-based heart repair
May. 15, 2015—A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells.
New player in heart cell growth
Apr. 6, 2015—Vanderbilt researchers have identified a new protein involved in heart cell growth, which could improve understanding of pathologic cardiac hypertrophy.
Contributors to coronavirus ‘fitness’
Feb. 24, 2015—Understanding the role that host membrane modification plays in coronavirus replication is essential for developing novel approaches to block the viruses that cause SARS and MERS.
Kidney disease impacts HDL function
Feb. 11, 2015—Chronic kidney disease impairs the protective functions of HDL, Vanderbilt researchers report this month.
Cognitive changes in ‘standing’ syndrome
Jan. 13, 2015—Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals.
Does fish oil help prevent A-fib?
Jan. 9, 2015—Growing evidence suggests that fish oil, thought to directly prevent inflammation, oxidative stress and heart disease, may have limited clinical utility.
Atrial disease and hypertension links
Dec. 18, 2014—New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease.
Target for atherosclerosis therapies
Dec. 17, 2014—A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression.
Protein implicated in atherosclerosis
Nov. 25, 2014—Vanderbilt researchers have discovered a new target for the prevention of atherosclerotic plaque development and cardiovascular disease.
Overactive stress response in obesity
Nov. 7, 2014—An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.
Peptide quells “genomic storm”
Oct. 28, 2014—A cell-penetrating peptide developed at Vanderbilt blocks the signaling pathways that lead to lethal shock caused by bacterial infection.
Immune cells’ role in hypertension
Oct. 24, 2014—Vanderbilt researchers have discovered that certain immune cells contribute to the development of hypertension, suggesting novel targets for treating the disease.
