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NIA Archives

Reduced exercise capacity in ICU survivors

Sep. 22, 2022—ICU survivors who have impaired exercise capacity months after discharge may have damaged muscle mitochondria — the energy powerhouses of the cell, Vanderbilt researchers propose.

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Tracking the aging brain

Jun. 6, 2022—The macrostructure — volume, area and length — of the brain’s white matter is useful for studying aging and could be a sensitive marker for neurodegenerative disorders such as Alzheimer’s disease, Vanderbilt researchers reported.

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PET imaging probe for Alzheimer’s disease

Feb. 24, 2022—Vanderbilt researchers report on a new PET imaging probe that will be useful for exploring Alzheimer’s disease pathology.

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Ensuring the “best possible” medication history

Jan. 18, 2022—About 80% of hospital admission electronic records were missing a drug prescribed to an older adult, Vanderbilt researchers found, highlighting the need for a multipronged approach to address medication discrepancies and support safe prescribing practices.

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Pancreatic beta-cell booster

Oct. 28, 2021—Blocking inflammatory signaling improves beta-cell characteristics in a mouse model of type 2 diabetes and may provide added benefits to GLP-1R diabetes medications.

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Study links genetic variants, protein expression and human diseases

Oct. 21, 2021—An international research team has developed a new resource that connects genetic variants and protein expression, which is expected to speed the identification of genes that cause disease — and point to novel treatment strategies.

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Estrogen, depression and menopause

Aug. 23, 2021—A shift in emotional processing may help women adapt to lower estrogen after menopause —unless they have a history of major depressive disorder, Vanderbilt researchers have found.

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Mood and cognition after chemotherapy

Jul. 26, 2021—Validation of cognitive complaints appears to improve mood in patients with persistent chemotherapy-cognitive impairment, Vanderbilt researchers report.

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Delirium and mortality reexamined

Jul. 8, 2021—A multicenter study of ICU patients found that in the hospital, delirium was associated with a nearly three-fold increase in risk of death the following day, but after discharge there was no association between delirium and mortality.

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A compound to counteract aging?

Apr. 29, 2021—A compound that increases lifespan in yeast is offering clues to pharmacological approaches that might slow the aging process and improve health.

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Chemo for cancer lowers dementia risk

Mar. 22, 2021—Cancer chemotherapy lowered risk of Alzheimer’s disease and other neurocognitive disorders that disproportionately affect older people.

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Strength training for osteoarthritis

Mar. 18, 2021—High-intensity strength training is not more effective than low-intensity training or educational efforts for reducing knee pain in patients with osteoarthritis.

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