NIA Archives
Neural networks probe proteins
May. 9, 2023—A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.
Genetics and chronic pain
Apr. 20, 2023—Polygenic risk scores — scores that reflect the influence of common genetic variants — could be used to predict the likelihood of developing chronic overlapping pain conditions and guide biomarker and targeted prevention efforts.
Treating delirium detected in the ED
Mar. 7, 2023—Higher intensity physical or occupational therapy may be a useful intervention to shorten delirium duration in older hospitalized adults, Vanderbilt researchers recently reported.
How arterial “stiffness” may impair cognition
Jan. 24, 2023—New findings from Vanderbilt neurologists suggest that cardiovascular disease may increase the spaces surrounding blood vessels in the brain and lead to cognitive decline.
Machine learning predicts delirium
Jan. 23, 2023—Using machine learning based on electronic health records of ICU patients predicted new-onset delirium with 82% sensitivity, Vanderbilt researchers found.
Researchers develop framework for multiancestry genomic studies
Dec. 8, 2022—Vanderbilt researchers have developed a framework for the analysis of multiancestry, large-scale genomic studies across multiple biobanks.
Alzheimer’s risk factor and cognition
Nov. 8, 2022—Vanderbilt researchers found that a protein with roles in innate immunity worsens memory at baseline in carriers of APOE-e4, the strongest genetic risk factor for Alzheimer’s disease, further implicating neuroinflammation in cognitive decline.
Reduced exercise capacity in ICU survivors
Sep. 22, 2022—ICU survivors who have impaired exercise capacity months after discharge may have damaged muscle mitochondria — the energy powerhouses of the cell, Vanderbilt researchers propose.
Tracking the aging brain
Jun. 6, 2022—The macrostructure — volume, area and length — of the brain’s white matter is useful for studying aging and could be a sensitive marker for neurodegenerative disorders such as Alzheimer’s disease, Vanderbilt researchers reported.
PET imaging probe for Alzheimer’s disease
Feb. 24, 2022—Vanderbilt researchers report on a new PET imaging probe that will be useful for exploring Alzheimer’s disease pathology.
Ensuring the “best possible” medication history
Jan. 18, 2022—About 80% of hospital admission electronic records were missing a drug prescribed to an older adult, Vanderbilt researchers found, highlighting the need for a multipronged approach to address medication discrepancies and support safe prescribing practices.
Pancreatic beta-cell booster
Oct. 28, 2021—Blocking inflammatory signaling improves beta-cell characteristics in a mouse model of type 2 diabetes and may provide added benefits to GLP-1R diabetes medications.
