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NICHD Archives

Genetics and blood pressure

May. 19, 2022—Including polygenic risk scores for blood pressure may improve predictive models to identify people at risk for treatment-resistant hypertension.

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Gene variants and transplant drug dose

May. 9, 2022—Genotyping multiple enzymes that metabolize the immunosuppressive drug tacrolimus — common used for lung transplant recipients — is important for correct dosing of the drug, Vanderbilt researchers found.

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Calculating risk for uterine fibroids

Apr. 26, 2022—Vanderbilt researchers have constructed a polygenic risk score for uterine fibroids that will be useful for exploring causes of these benign tumors and identifying novel drug targets and therapies.

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High blood pressure genes improve heart surgery survival in children

Mar. 24, 2022—Vanderbilt researchers have found that children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery.

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Invasive strep can defy zinc toxicity

Feb. 28, 2022—Vanderbilt researchers find that invasive Group B Streptococcus strains, a significant risk to pregnant patients and infants, can grow in presence of toxic zinc levels.

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Fibroids and preterm birth

Sep. 30, 2021—In a large, prospective study, Vanderbilt researchers found no association between fibroids and any clinical subtype of preterm birth, supporting a reconsideration of the impression that fibroids increase preterm birth risk.

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Medical diagnoses in musicians

Sep. 6, 2021—Vanderbilt researchers mined electronic health records to find medical diagnoses that are more or less prevalent among musicians, who are present in large numbers in “Music City.”

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Autoimmunity advance

Aug. 24, 2021—Vanderbilt researchers have developed a high-throughput screening method to identify and characterize antigen-specific B cells — potential biomarkers for autoimmune disease and targets for new treatments.

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Genetic ancestry and hypertension risk

Apr. 29, 2021—Racial disparities in hypertension risk are due in part to genetic differences between ancestries, Vanderbilt investigators find in a study of participants in the Million Veteran Program.

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Functional seizures associated with stroke, psychiatric disorders in electronic health records study

Jan. 7, 2021—In a large-scale study of electronic health records, Vanderbilt University Medical Center investigators have determined the prevalence of functional seizures and characterized comorbidities associated with them.

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Preserving gut mucus architecture

Oct. 20, 2020—A new method that keeps microbes and gut cells together will be useful for studies of complex host-microbe interactions and for analysis of clinical specimens.

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Fibroids and birth outcomes

Sep. 8, 2020—Women with three or more uterine fibroids — non-cancerous growths — during pregnancy are more likely to have infants with reduced birthweight and may need additional surveillance.

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