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nida Archives

Histamine circuits in brain reward center

Oct. 29, 2020—Histamine — commonly associated with allergies — also has a signaling role in the brain’s reward center and may offer a novel target for treating addiction.

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Land of plenty (of opioids)

Aug. 24, 2020—Surgical patients are being given more opioids than they need for postsurgical pain management, raising the risk of addiction.

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Blocking stress-induced relapse

Mar. 19, 2020—Danny Winder and colleagues are teasing apart the actions of neurotransmitter receptors in a brain region linked to anxiety and addiction, with a goal of finding treatments for substance use disorders.

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Cell fate signaling

Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

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Defective transporter linked to autism

Jul. 24, 2019—A first-of-its-kind mouse model may help reveal mechanistic underpinnings for the altered behaviors of autism spectrum disorder.

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Personalized pain management

Feb. 28, 2019—Understanding how natural brain chemicals with pain-relieving properties interact with administered opioids may guide personalized approaches for pain management.

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Modulating stress circuits

Feb. 14, 2019—Danny Winder and colleagues demonstrate an interaction between two signaling pathways — and its impact on the activity of neurons that respond to stress.

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Signals from the “conveyor belt”

Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

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Cytokine-cognition connection

Oct. 1, 2018—Targeting the immune system may provide a new avenue for therapeutic intervention in psychiatric diseases characterized by motivational and cognitive deficits.

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Investigators find that bile acids reduce cocaine reward

Aug. 30, 2018—Bile acids — gut compounds that aid in the digestion of dietary fats — reduce the desire for cocaine, according to a new study by researchers at Vanderbilt and the University of Alabama at Birmingham.

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Shaping reward circuits

May. 18, 2018—Using techniques to control and monitor the activities of individual neurons, Vanderbilt investigators are probing the brain’s reward circuitry.

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An immune regulator of addiction

Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.

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