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NIDDK Archives

Study supports removing race from estimate of kidney function

Nov. 17, 2022—An in-depth analysis by Vanderbilt investigators of published research studies supports removing race from the calculation of estimated glomerular filtration rate (eGFR) — an assessment of kidney function.

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Gene mutations impair gut barrier

Nov. 7, 2022—Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

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C. diff infections drop in children

Nov. 3, 2022—The number of pediatric infections caused by Clostridioides difficile (C. diff) decreased from 2013 to 2019, likely due to an increase in antibiotic stewardship programs and improved hospital contact protocols, Vanderbilt researchers found.

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Metabolic signatures of Type 2 diabetes risk

Oct. 24, 2022—Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.

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Aging beta cells hasten Type 2 diabetes

Oct. 20, 2022—Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

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Stress, obesity and food intake

Oct. 6, 2022—Vanderbilt researchers are elucidating the neuronal pathways that contribute to food consumption in response to stress — “comfort feeding” — and how they differ in males versus females and in the context of obesity.

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Gender differences with bladder pain

Sep. 26, 2022—Gender differences in the pain experiences and treatment needs of people with a urologic pain syndrome could be used to improve interventions, Vanderbilt researchers report.

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Nerve cells and cancer progression

Sep. 22, 2022—Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.

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Diabetes research grant receives NIDDK renewal

Sep. 8, 2022—The Vanderbilt Diabetes Research and Training Center is celebrating its 49th year of continual operation with the five-year competitive renewal of a $10.9 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health.

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Immune cells drive beta cell loss in Type 2 diabetes

Sep. 8, 2022—Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.

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Study identifies key player in T cell “education”

Sep. 1, 2022—New Vanderbilt research could inform therapeutic strategies for enhancing thymic function when desired — such as during aging, recovery from radiation therapy or chemotherapy, or other conditions that reduce T cell output.

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Vanderbilt researchers discover how gut inflammation leads to bone loss

Aug. 25, 2022—Gastrointestinal inflammation, such as occurs in inflammatory bowel disease, triggers the expansion of a population of “bone-eating” cells, leading to bone loss.

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