NIDDK Archives
New phenotyping program to bolster global diabetes research efforts
Nov. 9, 2017—The use of human pancreatic islets to conduct diabetes-related research has greatly expanded in recent years, and a Human Islet Phenotyping Program (HIPP) at Vanderbilt University Medical Center has been established to provide important islet data to investigators worldwide.
Gut response to fluid flow
Oct. 26, 2017—Vanderbilt researchers have discovered that microvilli – finger-like projections from cells in the intestine – respond to the shear stress of fluid flow to drive a cellular pathway that regulates nutrient balance.
New tools to combat kidney fibrosis
Oct. 13, 2017—Vanderbilt investigators have developed a new mouse model of kidney fibrosis, which provides a platform for identifying new targets and treatment strategies.
Boosting sarcoma cell death
Oct. 4, 2017—A compound identified at Vanderbilt represents a new lead for treating rare, aggressive childhood cancers called Ewing sarcomas.
Novel insights to antibiotic targets
Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.
Cellular calcium handling in diabetes
Sep. 28, 2017—Potassium channels in a cellular organelle regulate calcium flux and appear to play a critical role in pancreatic beta cell health.
Major grant to enhance kidney disease research
Sep. 28, 2017—Vanderbilt’s Division of Nephrology and Hypertension has received a five-year, $5 million federal grant to provide core research services in the fight against kidney disease.
Acid reflux cancer link
Sep. 14, 2017—Blocking acid reflux-induced production of reactive oxygen compounds may be a useful strategy for preventing DNA damage and decreasing the risk of esophageal cancer.
Early drivers of gastric cancer
Aug. 8, 2017—Using bioinformatics approaches, Vanderbilt investigators have identified gene expression networks that are deregulated in mouse and human stomach cancers.
HDAC3 role in B-cell development
Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.
Student’s summer research program honors her mother
Jul. 27, 2017—As a teenager, Ashley Duhon realized she wanted to become a doctor so she could help people, like her mother, who suffer from medical complications due to type 1 diabetes.
VUMC team’s discovery could lead to new diabetes treatment
Jun. 15, 2017—High circulating glucose, the hallmark of diabetes, is linked to the disease’s most serious complications including heart disease, kidney failure, blindness and amputation. Diabetes is the sixth leading cause of death and costs the nation an estimated $322 billion a year. Restoring the action of insulin has been the traditional treatment route. Insulin, a hormone...
