NIDDK Archives

Obesity sends immune cells to the brain

Feb. 12, 2014—Obesity causes peripheral immune cells to move to the brain, where they may contribute to inflammation and the pathophysiology of obesity.

New direction for treating lung cancer

Feb. 7, 2014—Targeting the production of molecules that promote tumor blood vessel development offers a new path for treating lung cancer.

Is healthy obesity possible?

Jan. 29, 2014—It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity.

Human and Helicobacter co-evolution

Jan. 23, 2014—by Denise Anthony A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast? The answer is disruption of co-evolution...

Therapeutic target for gastric cancer

Dec. 12, 2013—A protein kinase linked to inflammation and tumor development may be a good target for gastric cancer therapies.

Neurotransmitter’s role in bone balance

Nov. 7, 2013—Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling.

Relaxin combats insulin resistance

Oct. 16, 2013—The hormone relaxin may offer a novel approach for treating diet-induced insulin resistance.

Cell changes en route to stomach cancer

Sep. 26, 2013—Molecular characterization of pre-cancerous changes in cells lining the stomach could point to lesions with a greater risk of progression to cancer.

Probing intestinal immune cell roles

Aug. 28, 2013—A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions.

Tumor factor spurs blood vessel growth

Aug. 26, 2013—A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies.

Noninvasive test detects stomach bug

Aug. 12, 2013—A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer.