NIDDK Archives

Food variety drives overeating in mouse model of obesity syndrome

Apr. 25, 2013—Dietary variety – not high-fat or sugary foods – appears to stimulate overeating in a mouse model of an inherited obesity syndrome.

‘Longevity’ gene aids kidney survival

Apr. 17, 2013—A gene associated with cell survival and longevity may protect the kidney from acute injury.

“Silent” B cells trigger autoimmunity

Apr. 3, 2013—Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.

Plant compound stops colon cancer cells

Mar. 29, 2013—Berberine, an herbal remedy for diarrhea and intestinal parasites, may be useful in colon cancer therapy.

IRF6 on the tip of tongue development

Mar. 18, 2013—The factor IRF6 plays important roles in the development of the tongue.

Target for inflammatory bowel disease

Mar. 1, 2013—The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments.

Pancreas cells full of potential

Feb. 18, 2013—Adult cells in the pancreas can return to a less mature state – and then become a different cell type, like the beta cells that secrete insulin.

Linking oxygen, iron and red blood cells

Feb. 6, 2013—The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

Do-it-yourself repair in the kidney

Jan. 31, 2013—The kidney can mediate its own repair through proliferation of resident immune system cells.

HDL cholesterol impaired in kidney disease

Jan. 21, 2013—HDL cholesterol is impaired in patients with chronic kidney disease – and may increase their cardiovascular disease risk.

Study helps define pancreatic cancer’s cellular origins

Jan. 17, 2013—Vanderbilt and University of California investigators have discovered the “cell of origin” for pancreatic ductal adenocarcinoma, a finding that could lead to early detection methods and new treatments.