NIDDK Archives
Impaired neutrophils in autoimmunity
Jan. 27, 2022—Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity.
The role of integrins in kidney “integrity”
Jan. 13, 2022—Receptors called integrins play a critical role in maintaining the structure of the kidney, Vanderbilt researchers have discovered.
Salmonella overcomes host resistance
Jan. 13, 2022—The invading pathogen Salmonella, a common cause of food poisoning, can change its metabolism to overcome host resistance to its colonization.
CRISPR screen identifies new anti-inflammatory drug target
Nov. 11, 2021—A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics.
New way to bEET insulin resistance
Nov. 11, 2021—Signaling molecules called EETs could improve insulin resistance, a primary risk factor for Type 2 diabetes and cardiovascular disease, Vanderbilt researchers have discovered.
Harrison Society researcher discovers key regulator of kidney cell structure
Nov. 4, 2021—New research from Vanderbilt could aid efforts to promote kidney regeneration after injury or to develop engineered organs.
Pancreatic beta-cell booster
Oct. 28, 2021—Blocking inflammatory signaling improves beta-cell characteristics in a mouse model of type 2 diabetes and may provide added benefits to GLP-1R diabetes medications.
New marker for metaplasia
Oct. 14, 2021—A protein that transports water, called aquaporin 5, is expressed by cells undergoing changes that may increase risk for gastric cancer development, Vanderbilt researchers discovered.
Molecular imaging of C. diff infection
Sep. 30, 2021—C. difficile — the leading cause of hospital-associated intestinal infections — induces a rapid influx of bile acids into the gut, which could provide a novel target for blocking infection.
‘Pre-conditioning’ restores immune tolerance
Sep. 16, 2021—A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered.
Regulators of fat cell metabolism
Sep. 7, 2021—Vanderbilt researchers have discovered new details of the regulation of fat cell metabolism, findings that are important for combating obesity.
Autoimmunity advance
Aug. 24, 2021—Vanderbilt researchers have developed a high-throughput screening method to identify and characterize antigen-specific B cells — potential biomarkers for autoimmune disease and targets for new treatments.
