NIGMS Archives
Study details regulation of a multi-drug transporter
May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
The dynamic basement
May. 9, 2019—Vanderbilt scientists led by Andrea Page-McCaw have discovered a new way to analyze repair of basement membranes — important structural and functional components of tissues.
A new antibiotic’s mechanism of action
Apr. 25, 2019—Vanderbilt investigators have characterized how a new first-in-class antibacterial drug works, which will guide the development of additional compounds that overcome antibacterial resistance.
Study merges big data and zebrafish biology to reveal mechanisms of human disease
Apr. 24, 2019—In a series of studies that volleyed between large databases and research in zebrafish, Vanderbilt investigators have discovered a link between vascular biology and eye disease.
The arrestin-GPCR connection
Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.
How bugs overcome host defenses
Apr. 11, 2019—Vanderbilt researchers led by Eric Skaar are probing the mechanisms bacteria use when faced with nutrient starvation — a host defense strategy called “nutritional immunity.”
Drug interaction causes hypotension
Mar. 28, 2019—A muscle relaxing-drug and inhibitors of the metabolic enzyme CYP1A2 interact to cause severely low blood pressure and should not be co-prescribed, Vanderbilt investigators caution.
Unraveling endocytosis
Mar. 28, 2019—New discoveries by Jason MacGurn and colleagues further understanding of the complex machinery that cells use take up substances from outside the cell.
Achilles’ heel for kidney cancer
Feb. 28, 2019—The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.
Personalized pain management
Feb. 28, 2019—Understanding how natural brain chemicals with pain-relieving properties interact with administered opioids may guide personalized approaches for pain management.
Novel DNA repair mechanism preserves genome integrity: study
Feb. 28, 2019—Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.
The yin and yang of cell signaling
Feb. 14, 2019—Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.
