NIH Archives
Bone metabolism changes with aging
Sep. 14, 2023—Vanderbilt researchers have detailed how aging alters the metabolism of bone-forming cells, which could contribute to age-related osteoporosis.
Low-flow cerebrospinal fluid in Huntington’s disease: study
Sep. 7, 2023—Vanderbilt researchers found reduced net flow of cerebrospinal fluid in Huntington’s disease, which could contribute to mutant protein retention and altered responsiveness to medications delivered via the spinal cord.
MicroRNAs in immune cells help protect against metabolic defects in obesity: study
Sep. 5, 2023—Vanderbilt researchers have demonstrated that a cluster of microRNAs — small pieces of RNA that regulate gene expression — work in a type of immune cells called macrophages to help protect against metabolic defects in obesity.
New reference tool supports replication of DNA biobank studies
Aug. 31, 2023—Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.
Predicting postop opioid use
Aug. 24, 2023—VUMC study finds that preoperative patient characteristics can predict daily opioid use at six months after surgery, suggesting opportunities for development of electronic risk-stratification algorithms.
VUMC receives $51 million in NIH grants to improve efficiency of conducting clinical trials across the US
Aug. 9, 2023—Vanderbilt researchers have been awarded two five-year federal grants totaling $51 million to harness new and existing approaches for boosting recruitment and removing roadblocks to the efficiency of conducting clinical trials throughout the country.
Personalizing treatment for sinus syndrome
Aug. 2, 2023—Understanding the inflammatory characteristics of subtypes of chronic rhinosinusitis with polyps should assist with selection of effective therapies, Vanderbilt researchers report.
Signaling pathways in liposarcomas
Jul. 25, 2023—A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.
Rare disorder sheds light on dysbindin function
Jun. 27, 2023—A case study of a rare disorder uncovers roles for the protein dysbindin in the adaptive immune response and suggests that mutations may underlie some cases of very early onset inflammatory bowel disease.
Magnesium deficiency and blood pressure
Jun. 26, 2023—Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.
Pathways to a healthy liver
Jun. 22, 2023—Hepatic stellate cells maintain liver mass and function; the signaling factors they use could be exploited therapeutically to promote liver regeneration and inhibit cancerous proliferation, Vanderbilt researchers suggest.
Mosaicism and genetic disease
Jun. 22, 2023—Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.
