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NIH Archives

Delirium and mortality reexamined

Jul. 8, 2021—A multicenter study of ICU patients found that in the hospital, delirium was associated with a nearly three-fold increase in risk of death the following day, but after discharge there was no association between delirium and mortality.

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Genetics of hydrocephalus

Jul. 8, 2021—Fluid build-up in the brain — hydrocephalus — increases pressure and risk for brain damage; Vanderbilt researchers have now identified genes and signaling pathways associated with the condition.

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Gene variant linked to unnecessary bone marrow biopsies in African Americans

Jun. 28, 2021—A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine.

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New neurodegeneration culprit

Jun. 17, 2021—A young woman with a puzzling neurological illness and novel genetic variant pointed investigators to a role for dysregulated protein kinase D1 in neurodegeneration.

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VUMC joins national effort to improve disease prediction in diverse populations

Jun. 16, 2021—Vanderbilt University Medical Center will participate in a new federal initiative aimed at improving the use of polygenic risk scores (PRS) to predict complex diseases in diverse populations.

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Heat for hypertension in autonomic failure

May. 25, 2021—Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure.

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Therapeutic antibodies for hantavirus

May. 24, 2021—Vanderbilt Vaccine Center researchers have isolated monoclonal antibodies against hantaviruses, an emerging source of human disease with pandemic potential.

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New clue to lung scarring

May. 20, 2021—Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases.

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Beta cell regeneration

May. 20, 2021—Vanderbilt researchers dissected the complex microenvironment of the pancreatic islet to discover the signals that drive beta cell regeneration — as a possible treatment for diabetes.

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VUMC to lead national study to treat severe COVID complications

May. 6, 2021—The Vanderbilt Institute for Clinical and Translational Research (VICTR) has been awarded a major federal grant to lead a national trial of treatments targeting the Renin Angiotensin Aldosterone System (RAAS) in patients hospitalized with COVID-19.

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Study finds that regulatory protein prevents signaling that triggers cell death

May. 6, 2021—A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

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New strategy to treat brain bleeding

May. 4, 2021—Vasorelaxing peptides could offer a promising therapeutic strategy for reducing the neurological deficits caused by subarachnoid hemorrhage-induced cerebral blood vessel constriction.

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