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NINDS Archives

Cognitive changes in ‘standing’ syndrome

Jan. 13, 2015—Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals.

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Overactive stress response in obesity

Nov. 7, 2014—An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial.

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Neuronal culprit in genetic disease

Oct. 14, 2014—A particular neuronal cell population is involved in the pathogenesis of a rare neurological disorder, Vanderbilt researchers have discovered.

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Schizophrenia ‘switches’ discovered

Sep. 12, 2014—Drugs developed at Vanderbilt could provide a new way to treat schizophrenia in a personalized way.

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Myelin junctions key to conduction

Apr. 11, 2014—A protein in the myelin coating on nerves helps form a “seal” that enables effective nerve conduction; loss of the protein causes inherited neuropathies.

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A pain in the … genes

Jan. 10, 2014—Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception.

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VU study points to central regulator of neuron development

Dec. 12, 2013—Developmental biologist Chin Chiang, Ph.D., and his colleagues have discovered that Purkinje neurons in the cerebellum act as central regulators of neuronal development.

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Gene ‘dose’ may be key to autism

Mar. 4, 2013—Individuals with overexpression of the gene MECP2 have core features of autism spectrum disorder.

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How ‘Jedi’ disposes of dead neurons

Sep. 19, 2012—The protein Syk is essential for clearing away neuron “corpses” in the developing peripheral nervous system.

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Neuronal subtypes in genetic disorder

Sep. 6, 2012—Inhibitory neurons that connect and regulate signaling in the brain (interneurons) may contribute to epilepsy and autism in patients with tuberous sclerosis complex.

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Insights for neuroscience drug discovery

Jul. 17, 2012—When discovering drugs for brain disorders, it’s important to test the candidates in multiple ways to avoid advancing those with restricted physiological effects.

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Roots of childhood brain tumors

Jun. 14, 2012—Cells in the back of the developing brain can give rise to brain tumors, suggesting they may be a target for treatment.

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