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P450 Archives

Codeine metabolizer status in clinical practice

Apr. 5, 2021—Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine.

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Steroid binding to metabolic enzyme

Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Antacids: risky for premature babies

Jun. 12, 2013—Antacids that block a certain enzyme pose a risk for a common cardiac problem in premature infants.

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An orphan enzyme’s purpose

Oct. 4, 2012—“Orphan” enzyme may play role in cancer growth, new research suggests.

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