Family’s participation key to advancing diabetes research
Mar. 9, 2023—A study of one family from Alabama has led Vanderbilt researchers to discover that insulin deficiency, independent of the autoimmunity associated with Type 1 diabetes, is the principal factor leading to a markedly smaller pancreas.
Addition to pancreatic image bank expected to help advance diabetes research worldwide
Oct. 14, 2022—An image bank of samples of the pancreas from children who developed diabetes shortly before death has gone live at Vanderbilt University Medical Center, with the aim to advance global medical research in the diabetes field.
Nerve cells and cancer progression
Sep. 22, 2022—Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.
Immune cells drive beta cell loss in Type 2 diabetes
Sep. 8, 2022—Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.
Study proves standardized protocol can support reliable MRI use for multisite pancreatic research
Aug. 27, 2021—Researchers with the Vanderbilt Diabetes Research and Training Center (DRTC) at Vanderbilt University Medical Center led a multisite study which has demonstrated that, when controlled and standardized, quantitative magnetic resonance imaging (MRI) of the pancreas is highly reproducible when using different MRI hardware and software at different geographic locations.
Pancreatlas provides access to complex images of the human pancreas
Dec. 22, 2020—Images of cells and tissues are a critical part of biomedical research as they show which molecules or proteins are present and where these molecules are located in the tissue. Using increasingly sophisticated microscopes and imaging approaches, scientists can now look at more than 40 different molecules at once, an approach known as multi-plex imaging, where in the past they could only look at three or four molecules at a time.
Pseudoislet system expected to advance pancreas and diabetes research
Jul. 30, 2020—The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but Vanderbilt University Medical Center researchers have now developed a pseudoislet system that allows for much easier study of islet function.
Keeping beta cells “fit”
Jul. 9, 2020—Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression.
Study expands insight on shrinking pancreas in type 1 diabetes
Apr. 25, 2019—Researchers with the Vanderbilt Diabetes Research and Training Center (DRTC) have discovered a progressive decline in pancreas volume over a one-year period in children and adolescents with newly diagnosed Type 1 diabetes.
Building a pancreas
Jan. 17, 2019—Vanderbilt investigators are defining the genetic programs that control the development of pancreatic beta cells — studies that could inform new cellular or regenerative therapies for diabetes.
Patient’s freak pancreas injury spurs rapid response
Sep. 14, 2017—Macie Glover sprinted across the gym floor at school earlier this year, tripped and crashed into a wall. In a bizzare sequence of events, she hit her head and arm and scraped her knees as the force of the crash propelled her whole body arching backward into a crescent shape.
Making human beta cells reproduce
Dec. 8, 2016—A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells.