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pathology microbiology and immunology Archives

VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment

Jan. 5, 2021—Researchers at Vanderbilt University Medical Center and Case Western Reserve University in Cleveland have been awarded a five-year, $3.3 million grant by the National Cancer Institute to apply artificial intelligence (AI) to help customize treatment for oral cancer patients.

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Exploiting viral vulnerabilities

Dec. 10, 2020—The isolation of human monoclonal antibodies against dangerous viruses including EEEV, Hendra and Nipah could offer new ways to treat and prevent these infections.

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Study details early events of inflammatory response

Dec. 10, 2020—Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.

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Coogan named chair of Pathology, Microbiology and Immunology

Dec. 8, 2020—After an extensive national search Alice Coogan, MD, interim chair of the Department and professor of Pathology, Microbiology and Immunology (PM&I), has been named as the department’s next chair, effective immediately. Coogan will be the seventh chair of the department and the first female chair.

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Team tracks sources of false positives in urine drug screens

Dec. 3, 2020—False positives on urine drug screens are common and are frequently due to cross-reactivity of these tests to medications. Last year, Vanderbilt University Medical Center researchers Jacob Hughey, PhD, assistant professor of Biomedical Informatics, and Jennifer Colby, PhD, at that time assistant professor of Pathology, Microbiology and Immunology, devised, tested and published a method to systematically identify medications that interfere with screenings for drugs of abuse.

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V Scholar Award to support Byndloss’ cancer research

Nov. 18, 2020—Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology, has received a V Scholar Award to support her studies of the links between obesity, the gut microbiome and colorectal cancer.

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Frog peptides as anti-HIV microbicides

Nov. 2, 2020—Peptides derived from the antimicrobial peptides secreted by frogs could function as microbicides to limit HIV transmission, while sparing protective vaginal bacteria.

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Early steps in reovirus replication

Oct. 6, 2020—Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found.

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Rational vaccine design

Sep. 22, 2020—Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development.

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Probing pathogen antibiotic resistance

Sep. 17, 2020—Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics.

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The importance of estrogen cycles

Aug. 6, 2020—Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer.

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Stomach bug hit-and-run

Jul. 23, 2020—The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate.

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Recent Stories from VUMC News and Communications Publications

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