PheWAS Archives
New reference tool supports replication of DNA biobank studies
Aug. 31, 2023—Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.
PheWAS reveals post-COVID-19 diagnoses
Sep. 8, 2022—Using a high-throughput informatics technique and electronic health records, Vanderbilt researchers found that COVID-19 survivors had an increased risk for more than 40 new diagnoses.
Studies combine genetic testing, electronic health records to find undiagnosed diseases
Apr. 28, 2022—Combining genetic testing with information from electronic health records revealed undiagnosed heart rhythm disorders and new conditions associated with inherited cancer gene mutations.
Medical diagnoses in musicians
Sep. 6, 2021—Vanderbilt researchers mined electronic health records to find medical diagnoses that are more or less prevalent among musicians, who are present in large numbers in “Music City.”
Computer-based study reveals impact of race on health
Oct. 8, 2020—A computer-based method developed at Vanderbilt University Medical Center that scans electronic medical records (EMRs) for genetic contributors to disease has been used for the first time to reveal the impact of race on health.
PheWAS Core helps researchers make sense of electronic health record data
Feb. 7, 2019—Some biomedical researchers may be unsure about routine electronic health record (EHR) data and how useful it ultimately may prove for drawing meaningful, actionable associations that warrant changes to clinical practice and lead to improved clinical outcomes.
Research bolsters thyroid function, atrial fibrillation link
Jan. 31, 2019—A study by researchers at Vanderbilt University Medical Center has strengthened the link between thyroid function and atrial fibrillation (AF), an irregular heart rhythm that increases the risk of stroke and other heart-related complications.
Connecting an asthma gene to leukemia
Aug. 2, 2018—A receptor previously implicated in asthma may also play roles in other allergic diseases and in leukemia, Vanderbilt researchers have discovered.
Team explores diabetes drug’s ability to treat RSV infection
Jul. 12, 2018—A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.
Scientists create unique disease ‘catalog’ linked to immune system gene variations
May. 10, 2017—A study led by researchers at Vanderbilt University Medical Center (VUMC) and the University of Arizona College of Pharmacy has generated the first comprehensive catalog of diseases in a single population associated with variations in HLA genes that regulate the body's immune system.
Rheumatoid subtypes explored by PheWAS
Oct. 7, 2016—A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.
Study applies random genotype sets to new disease
Jan. 5, 2012—A new study in the American Journal of Human Genetics, led by Vanderbilt researchers Josh Denny, M.D., M.S., and Dana Crawford, Ph.D., takes random volumes of human genotypes and matches them with data siphoned from de-identified medical records and sheds new light on the genetic basis of the common disease hypothyroidism. In a research lab,...
