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pierre massion Archives

Study finds AI can categorize cancer risk of lung nodules

May. 7, 2020—by Tom Wilemon Computed tomography scans for people at risk for lung cancer lead to earlier diagnoses and improve survival rates, but they can also lead to overtreatment when suspicious nodules turn out to be benign. A study published in American Journal of Respiratory and Critical Care Medicine indicates that an artificial intelligence strategy can correctly assess and categorize these indeterminate pulmonary nodules (IPNs). When compared to the conventional risk models clinicians currently use, the algorithm developed by the team of researchers in a very large dataset (15,693 nodules) reclassified IPNs into low-risk or high-risk categories in over a third of cancers and benign nodules. “These results suggest the potential clinical utility of this deep learning algorithm to revise the probability of cancer among IPNs aiming to decrease invasive procedures and shorten time to diagnosis,” said Pierre Massion, MD, Cornelius Vanderbilt Chair in Medicine at Vanderbilt University, the study’s lead author. Currently, clinicians refer to guidelines issued by the American College of Radiology and the American College of Chest Physicians. Adherence to these guidelines can be variable, and how patient cases are classified can be subjective. With the goal of providing clinicians with an unbiased assessment tool, the researchers developed an algorithm based on datasets from the National Lung Screening Trial, Vanderbilt University Medical Center and Oxford University Hospital. Their study is the first to validate a risk stratification tool on multiple independent cohorts and to show reclassification performance that is significantly superior to existing risk models. With IPNs, clinicians are often faced with the dilemma of weighing whether to advise a patient to undergo an invasive surgical procedure, which may be unnecessary, against a watch-and-wait strategy, which may result in delaying needed cancer treatment. A definitive diagnosis of an IPN can take up to two years. Better assessment tools are needed by clinicians as screenings for patients at risk for lung cancer increase. Lung cancer is the leading cause of cancer-related death in the United States and globally. The overall five-year survival rate is 21.7%, but it is much greater (92%) for those patients who receive an early diagnosis of stage IA1 non-small cell cancer. n

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Study tracks genomics of lung tumor behavior

Apr. 9, 2020—A study by Vanderbilt researchers has identified genomic alterations in early stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors.

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Lung cancer survival signal

Nov. 29, 2018—A receptor thought to be a cell growth inhibitor actually sends pro-survival signals in small cell lung cancer and is a candidate biomarker for poor prognosis.

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A new target for lung cancer

Aug. 16, 2018—Vanderbilt researchers have identified a new vulnerability in lung cancer — the transporter protein xCT — that may a therapeutic target for the disease.

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Veterans Affairs Research Conference

Jun. 1, 2017—The 3rd National Veterans Health Affairs Research Conference held at Vanderbilt University Medical Center May 17-18.

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Team’s discovery offers new insight on lung cancer risk

Jan. 12, 2017—Researchers in the Schools of Medicine and Engineering at Vanderbilt University have discovered a proteomic “signature” from the airways of heavy smokers that could lead to better risk assessment and perhaps new ways to stop lung cancer before it starts.

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Grant spurs study of novel imaging technique for COPD

Sep. 15, 2016—Vanderbilt researchers have received an R01 grant from the National Institutes of Health to study a novel non-invasive imaging approach to detect activation of inflammatory cells in the lungs of patients with chronic obstructive pulmonary disease (COPD), a progressive lung condition that makes breathing difficult.

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Massion named to lead new cancer prevention initiative

Jul. 28, 2016—Pierre Massion, M.D., Cornelius Vanderbilt Professor of Medicine, has been named to direct the Vanderbilt-Ingram Cancer Center (VICC) Cancer Early Detection and Prevention Initiative.

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Ten Vanderbilt faculty members elected AAAS fellows

Nov. 23, 2015—Ten members of Vanderbilt University’s faculty have been elected fellows of the American Association for the Advancement of Science.

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Potential target for lung cancer therapy

Oct. 5, 2015—The glutamine transporter protein appears to contribute to the survival of lung cancer cells, suggesting it may be a useful diagnostic biomarker and target for therapies.

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Lung cancer foundation lauds Massion’s contributions

Jun. 11, 2015—Pierre Massion, M.D., director of the Thoracic Program and an Ingram Professor of Cancer Research at Vanderbilt-Ingram Cancer Center, has been recognized for his pioneering work in lung cancer by the LUNGevity Foundation.

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Event celebrates new holders of endowed chairs at Vanderbilt

Apr. 23, 2015—Seven faculty members of the Vanderbilt University School of Medicine named to endowed chairs were honored for their academic achievements during a celebration on Wednesday at the Student Life Center.

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Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

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