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PNAS Archives

Brain lesions and criminal behavior linked to moral decision-making network

Dec. 18, 2017—When brain lesions occur within the brain network responsible for morality and value-based decision-making, they can predispose a person toward criminal behavior, according to new research by Ryan Darby, MD, assistant professor of Neurology at Vanderbilt University Medical Center (VUMC).

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An immune regulator of addiction

Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.

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HDAC3 role in B-cell development

Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

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Study finds common brain scanning technique maps electrical activity as precisely as more invasive methods

May. 25, 2017—A commonly used brain scanning technique can map electrical activity under the skull as precisely as more invasive methods that rely on probes or electrodes, researchers at Vanderbilt University Medical Center (VUMC) reported this month.

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A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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Study takes 3-D perspective on colorectal cancer

Mar. 23, 2017—Despite dramatic recent advances in treatment, colorectal cancer killed more than 49,000 Americans last year, according to the National Cancer Institute, making it the second most lethal malignancy after cancers of the lung and bronchus.

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Targeting norovirus “noxiousness”

Sep. 28, 2016—New discoveries will guide efforts to develop vaccines or antiviral agents for norovirus, the most common cause of infectious diarrhea.

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Team explores transcription factor’s autoimmunity role

Aug. 11, 2016—Increasing expression of a transcription factor called KLF2 can promote immunological self-tolerance and “tune down” autoimmunity, researchers at Vanderbilt University Medical Center reported recently.

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New pain medicine from a fungus?

May. 13, 2016—Collybolide – a natural product isolated from a mushroom – is a promising candidate for the development of non-addictive pain medicines.

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Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

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Slight chemical change may improve TB treatments: study

Feb. 11, 2016—One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.

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Dynamics of a drug resistance transporter

Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

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