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PNAS Archives

Copying chromosome caps

Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

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Compound developed at VUMC may delay Huntington’s disease

Oct. 29, 2015—A compound developed by researchers at Vanderbilt University can improve early symptoms and delay progression of Huntington’s disease in a mouse model of the neurodegenerative disorder.

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The yin and yang of COX-2

Oct. 2, 2015—New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

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Bridging the antibiotic gap

Aug. 7, 2015—Vanderbilt researchers have discovered how certain molecules with antibiotic properties are synthesized, findings that could lead to new drugs that overcome the increased antibiotic resistance in bacteria.

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How to trick a wily virus

Jul. 24, 2015—Vanderbilt investigators have discovered how human antibodies induced during testing of an experimental “bird flu” vaccine kill the virus.

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Study identifies C. diff toxin receptor, suggests new treatment approaches

Jun. 4, 2015—Vanderbilt University investigators have identified a cellular receptor for a toxin from Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.

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Study reveals biomarker of post-injury spinal cord function

Apr. 23, 2015—Vanderbilt University researchers have demonstrated, for the first time in a primate model, that injury disrupts neural signaling in the spinal cord and that these changes can be measured non-invasively with functional magnetic resonance imaging (fMRI).

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Study explores driver behind lung cancer tumor progression

Apr. 2, 2015—Vanderbilt-Ingram Cancer Center investigators have identified the mechanisms used by a gene and its binding protein to drive tumor growth in several forms of cancer, including non-small cell lung cancer.

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Immune response depends on force

Jan. 26, 2015—New studies explain how T-cell receptors use force to recognize and protect us against pathogens.

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New view of transporter dynamics

Oct. 23, 2014—New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.

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Lymphocyte study reveals obesity clues

Oct. 16, 2014—Vanderbilt University researchers are closer to understanding the link between obesity, chronic inflammation and type 2 diabetes.

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Team spots key regulator for cholesterol production

Oct. 2, 2014—A Vanderbilt University-led research team has discovered a “master regulator” for cholesterol production and transport in the liver — a tiny piece of RNA called microRNA-223.

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