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PNAS Archives

New technique accelerates genome editing process

Aug. 21, 2014—It sounds like a potato chip. But CRISPR is actually the acronym for a new genome editing technique that, by many accounts, is accelerating the study of genes and disease.

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Regulating immune regulators

Jul. 17, 2014—Understanding how to control the generation of regulatory T cells could have important implications for treating autoimmunity and cancer.

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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A new way to target cancer-driver Ras

Mar. 13, 2014—Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way.

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Human and Helicobacter co-evolution

Jan. 23, 2014—by Denise Anthony A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast? The answer is disruption of co-evolution...

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Ancient chemical bond may aid cancer therapy: study

Dec. 19, 2013—A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the “dawn of the animal kingdom” could lead to new therapies for cancer and other diseases.

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Defusing ‘C. diff’ infection

Nov. 8, 2013—Clostridium difficile (“C. diff”) infection is a leading cause of hospital-associated diarrhea, and the frequency and severity of infections are on the rise. D. Borden Lacy, Ph.D., associate professor of Pathology, Microbiology and Immunology, and colleagues recently demonstrated that the C. difficile toxin, TcdB, induces rapid cell death of human colon cell lines and pig colonic...

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Probing mutant EGF receptor regulation

Oct. 10, 2013—Understanding the regulation of mutant EGF receptors commonly found in lung cancers could lead to new targeted therapies.

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Food variety drives overeating in mouse model of obesity syndrome

Apr. 25, 2013—Dietary variety – not high-fat or sugary foods – appears to stimulate overeating in a mouse model of an inherited obesity syndrome.

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Antibacterial protein’s molecular workings revealed

Feb. 21, 2013—Vanderbilt investigators report new insights to the workings of calprotectin, an immune system protein that “starves” bacterial pathogens of the metal nutrients they require.

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Seeing light receptor’s interactions

Jan. 18, 2013—Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.

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Stomach bug alters tumor suppressor

Oct. 23, 2012—The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer.

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