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Proceedings of the National Academy of Sciences Archives

Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease

Jul. 20, 2020—Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

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“Nur” target may aid arthritis treatment

Jul. 13, 2020—Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.

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Study explores how staph bacteria can survive in bone

Jun. 3, 2020—A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.

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A dual-purpose metabolic switch

May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.

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Protein research seeks to induce tumor regression

Jan. 29, 2020—Understanding how MYC interacts with WDR5 and other cofactors could lead to the development of new drugs that can effectively block MYC and stop many cancers in their tracks.

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Imaging host-pathogen battle for metal

Oct. 31, 2019—An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.

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Less inflammation = better healing

Oct. 17, 2019—Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes.

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A step toward gastric cancer

Oct. 3, 2019—New research findings provide insight into the detrimental events that develop in response to H. pylori infection.

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Low oxygen and antibody responses

Apr. 25, 2019—Mark Boothby and colleagues are exploring the factors that contribute to antibody production and quality, which are key to our defense against pathogens and response to vaccines.

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Cancer prevention drug also disables H. pylori bacterium

Mar. 28, 2019—A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

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Designing antibodies to fight the flu

Jan. 31, 2019—Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.

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Signals from the “conveyor belt”

Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

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Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

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