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Proceedings of the National Academy of Sciences Archives

VUMC scientists record powerful signal in the brain’s white matter

Oct. 16, 2023—Vanderbilt researchers report that when people who are having their brains scanned by fMRI perform a task, like wiggling their fingers, certain signals increase in white matter throughout the brain, which has long been thought to play a lesser role the more the brain's more energetic gray matter.

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VUMC study reveals critical first steps to cancer

Sep. 20, 2023—A new study by Vanderbilt researchers provides a remarkably detailed view of the earliest events leading to the development of cancer, and of potential new ways to prevent it.

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Foundation funds research to block drug resistance in cancer treatment

Sep. 1, 2023—The Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation has funded an ambitious initiative to overcome one of the most perplexing and frustrating mysteries of cancer treatment — how to prevent drug resistance.

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Study may lead to new diabetes, heart disease treatments

Jan. 12, 2023—Vanderbilt research found that deletion of an autophagy-participating factor named PIK3C3 from the fat cells of mice led to compromised body temperature control, abnormal blood lipid levels, fatty liver and diabetes.

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Study finds sensitivity to musical rhythm supports social development in infants

Nov. 3, 2022—A new study shows engaging infants with a song provides a ready-made means for supporting social development and interaction.

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Study reveals need for matching targeted therapies with EGFR subtypes

Jul. 28, 2022—A Vanderbilt study suggests that clinicians should take a deeper dive into distinguishing EGFR mutations when prescribing targeted therapies for non-small-cell lung cancers.

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The power of white matter

Nov. 11, 2021—Using a novel analysis of fMRI data, Vanderbilt researchers discovered intriguing patterns of signals in the brain’s white matter, the “conduit” for relaying signals between different brain regions.

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New clue to lung scarring

May. 20, 2021—Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases.

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Novel way to neutralize Rift Valley Fever Virus

Apr. 1, 2021—The discovery of monoclonal antibodies that neutralize Rift Valley Fever Virus — an emerging infection with pandemic potential — lays the foundation for future therapeutic antibody development.

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Targeting glucagon action in diabetes

Mar. 4, 2021—Disrupting the action of glucagon — a pancreatic hormone that works to raise blood glucose — restores functional insulin-producing cells in mouse models of type 1 diabetes and may be a promising treatment strategy.

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Study details early events of inflammatory response

Dec. 10, 2020—Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.

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Assembling cell power plant machinery

Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.

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