Proceedings of the National Academy of Sciences Archives
Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease
Jul. 20, 2020—Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.
“Nur” target may aid arthritis treatment
Jul. 13, 2020—Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.
Study explores how staph bacteria can survive in bone
Jun. 3, 2020—A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.
A dual-purpose metabolic switch
May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.
Protein research seeks to induce tumor regression
Jan. 29, 2020—Understanding how MYC interacts with WDR5 and other cofactors could lead to the development of new drugs that can effectively block MYC and stop many cancers in their tracks.
Imaging host-pathogen battle for metal
Oct. 31, 2019—An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.
Less inflammation = better healing
Oct. 17, 2019—Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes.
A step toward gastric cancer
Oct. 3, 2019—New research findings provide insight into the detrimental events that develop in response to H. pylori infection.
Low oxygen and antibody responses
Apr. 25, 2019—Mark Boothby and colleagues are exploring the factors that contribute to antibody production and quality, which are key to our defense against pathogens and response to vaccines.
Cancer prevention drug also disables H. pylori bacterium
Mar. 28, 2019—A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.
Designing antibodies to fight the flu
Jan. 31, 2019—Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.
Signals from the “conveyor belt”
Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.
