Proceedings of the National Academy of Sciences Archives
Study reveals need for matching targeted therapies with EGFR subtypes
Jul. 28, 2022—A Vanderbilt study suggests that clinicians should take a deeper dive into distinguishing EGFR mutations when prescribing targeted therapies for non-small-cell lung cancers.
The power of white matter
Nov. 11, 2021—Using a novel analysis of fMRI data, Vanderbilt researchers discovered intriguing patterns of signals in the brain’s white matter, the “conduit” for relaying signals between different brain regions.
New clue to lung scarring
May. 20, 2021—Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases.
Novel way to neutralize Rift Valley Fever Virus
Apr. 1, 2021—The discovery of monoclonal antibodies that neutralize Rift Valley Fever Virus — an emerging infection with pandemic potential — lays the foundation for future therapeutic antibody development.
Targeting glucagon action in diabetes
Mar. 4, 2021—Disrupting the action of glucagon — a pancreatic hormone that works to raise blood glucose — restores functional insulin-producing cells in mouse models of type 1 diabetes and may be a promising treatment strategy.
Study details early events of inflammatory response
Dec. 10, 2020—Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.
Assembling cell power plant machinery
Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.
Cashew shell compound appears to mend damaged nerves
Aug. 17, 2020—In laboratory experiments, a chemical compound found in the shell of the cashew nut promotes the repair of myelin, a team from Vanderbilt University Medical Center reported Aug. 17 in the Proceedings of the National Academy of Sciences.
Study points to potential new approach to treating neurodegenerative diseases like glaucoma and Alzheimer’s disease
Jul. 20, 2020—Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.
“Nur” target may aid arthritis treatment
Jul. 13, 2020—Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.
Study explores how staph bacteria can survive in bone
Jun. 3, 2020—A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.
A dual-purpose metabolic switch
May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.
