Proceedings of the National Academy of Sciences Archives
Study explores how staph bacteria can survive in bone
Jun. 3, 2020—A comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus (“staph”) growth during invasive bone infections could offer new targets for treatment.
A dual-purpose metabolic switch
May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.
Protein research seeks to induce tumor regression
Jan. 29, 2020—Understanding how MYC interacts with WDR5 and other cofactors could lead to the development of new drugs that can effectively block MYC and stop many cancers in their tracks.
Imaging host-pathogen battle for metal
Oct. 31, 2019—An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.
Less inflammation = better healing
Oct. 17, 2019—Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes.
A step toward gastric cancer
Oct. 3, 2019—New research findings provide insight into the detrimental events that develop in response to H. pylori infection.
Low oxygen and antibody responses
Apr. 25, 2019—Mark Boothby and colleagues are exploring the factors that contribute to antibody production and quality, which are key to our defense against pathogens and response to vaccines.
Cancer prevention drug also disables H. pylori bacterium
Mar. 28, 2019—A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.
Designing antibodies to fight the flu
Jan. 31, 2019—Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.
Signals from the “conveyor belt”
Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.
DNA’s on/off switch
Jan. 17, 2019—DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.
New study looks at brain networks involved in free will
Oct. 3, 2018—Using lesion network mapping, a recently developed technique for analyzing how the brain works, Ryan Darby, MD, assistant professor of Neurology at Vanderbilt, studied free will perception related to movement decisions.
