Proceedings of the National Academy of Sciences Archives
Signals from the “conveyor belt”
Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.
DNA’s on/off switch
Jan. 17, 2019—DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.
New study looks at brain networks involved in free will
Oct. 3, 2018—Using lesion network mapping, a recently developed technique for analyzing how the brain works, Ryan Darby, MD, assistant professor of Neurology at Vanderbilt, studied free will perception related to movement decisions.
Energetic gene switch
Aug. 30, 2018—New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.
Predictive models for gene regulation
Aug. 16, 2018—Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.
Fueling the MATE transporter
Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
Understanding HDL structure
May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.
Iron-sulfur “intersection”
Mar. 8, 2018—Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.
BOLD view of white matter
Jan. 12, 2018—Vanderbilt investigators have discovered that functional MRI detects neural activity in both gray and white matter in the brain, suggesting new ways to investigate diseases such as Alzheimer’s and multiple sclerosis.
Lighting up iron levels
Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.
Brain lesions and criminal behavior linked to moral decision-making network
Dec. 18, 2017—When brain lesions occur within the brain network responsible for morality and value-based decision-making, they can predispose a person toward criminal behavior, according to new research by Ryan Darby, MD, assistant professor of Neurology at Vanderbilt University Medical Center (VUMC).
An immune regulator of addiction
Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.
