Proceedings of the National Academy of Sciences Archives
Energetic gene switch
Aug. 30, 2018—New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.
Predictive models for gene regulation
Aug. 16, 2018—Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.
Fueling the MATE transporter
Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
Understanding HDL structure
May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.
Mar. 8, 2018—Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.
BOLD view of white matter
Jan. 12, 2018—Vanderbilt investigators have discovered that functional MRI detects neural activity in both gray and white matter in the brain, suggesting new ways to investigate diseases such as Alzheimer’s and multiple sclerosis.
Lighting up iron levels
Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.
Brain lesions and criminal behavior linked to moral decision-making network
Dec. 18, 2017—When brain lesions occur within the brain network responsible for morality and value-based decision-making, they can predispose a person toward criminal behavior, according to new research by Ryan Darby, MD, assistant professor of Neurology at Vanderbilt University Medical Center (VUMC).
An immune regulator of addiction
Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.
HDAC3 role in B-cell development
Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.
Immune responses linked to cell’s recycling system
Jul. 20, 2017—Autophagy is the cellular equivalent of trash pickup and recycling — it is a process by which proteins, protein aggregates and damaged cellular organelles are degraded in order to reuse nutrients and promote cellular metabolism.
Study finds common brain scanning technique maps electrical activity as precisely as more invasive methods
May. 25, 2017—A commonly used brain scanning technique can map electrical activity under the skull as precisely as more invasive methods that rely on probes or electrodes, researchers at Vanderbilt University Medical Center (VUMC) reported this month.