Proceedings of the National Academy of Sciences Archives
A new mode of DNA repair
Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.
New target for chronic infection
Feb. 2, 2017—An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.
Research sheds light on how RSV wards off potential vaccines
Oct. 20, 2016—Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it.
Targeting norovirus “noxiousness”
Sep. 28, 2016—New discoveries will guide efforts to develop vaccines or antiviral agents for norovirus, the most common cause of infectious diarrhea.
VUMC researchers seek to crack the code of neonatal sepsis
Jun. 2, 2016—Sepsis, an exaggerated and overwhelming inflammatory response to infection, is a major worldwide killer of babies in the first four weeks of life (neonatal period).
New pain medicine from a fungus?
May. 13, 2016—Collybolide – a natural product isolated from a mushroom – is a promising candidate for the development of non-addictive pain medicines.
Improving natural killer cancer therapy
Apr. 29, 2016—A newly discovered mechanism that helps cancer cells avoid destruction by immune system cells may improve immunotherapies.
Fat hormone’s role in zebrafish
Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.
Slight chemical change may improve TB treatments: study
Feb. 11, 2016—One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.
Dynamics of a drug resistance transporter
Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.
Copying chromosome caps
Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.
Compound developed at VUMC may delay Huntington’s disease
Oct. 29, 2015—A compound developed by researchers at Vanderbilt University can improve early symptoms and delay progression of Huntington’s disease in a mouse model of the neurodegenerative disorder.