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Research Archives

Study finds genetic factor undermines H. pylori treatment

Aug. 4, 2021—Helicobacter pylori, a stomach-dwelling bacterium, is a strong risk factor for gastric cancer, peptic ulcers and other debilitating gastrointestinal disorders. Yet efforts to eradicate it using a combination of antibiotics and proton pump inhibitors (PPIs), which suppress gastric acid production, often fail.

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Vanderbilt Prize winner Doudna advocates caution in human germline editing

Jul. 29, 2021—It is now possible to “edit” the human germline — the genetic cargo carried in sperm and eggs and which is passed to the next generation — in a way that snips out the mutations which cause inherited disease.

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VUMC’s Wilkins lands major national award for women physicians

Jul. 23, 2021—Consuelo Wilkins, MD, MSCI, a leader in health equity, diversity and inclusion at Vanderbilt University Medical Center (VUMC), is the 2021 recipient of the Marion Spencer Fay Award from Drexel University College of Medicine in Philadelphia.

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Researchers discover that protein switches functions to regulate DNA replication

Jul. 22, 2021—Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

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For more precise drug treatments, ‘squeeze’ the genome: study finds

Jul. 22, 2021—Large-scale studies will be required to identify the complexity of genetic variations that affect how patients respond to a given drug and whether they will have side effects, according to researchers at Vanderbilt University Medical Center.

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Study identifies monoclonal antibodies that may neutralize many norovirus variants

Jul. 16, 2021—Researchers at Vanderbilt University Medical Center (VUMC) and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.

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Arterial stiffening linked to Alzheimer’s disease

Jul. 15, 2021—A research team from Vanderbilt University Medical Center reports in Neurology that greater stiffening of the aorta, the main artery in the human body, is associated in older adults with increased Alzheimer’s disease (AD) pathology as reflected in a range of neurochemical indicators measured in cerebrospinal fluid.

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Nature’s “recycler” could reduce heart disease risk: study

Jul. 8, 2021—Researchers at Vanderbilt University Medical Center have identified potential new targets for the prevention of atherosclerosis through the enhancement of autophagy, a natural process for recycling damaged cellular material.

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Study finds genetic risk factors for severe COVID-19 illness

Jul. 8, 2021—A massive worldwide collaboration including researchers from Vanderbilt University Medical Center (VUMC) has identified several genetic factors associated with SARS-CoV-2 infection and severe COVID-19 illness.

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Nobel laureate Doudna set for next Discovery Lecture

Jul. 7, 2021—Nobel laureate Jennifer Doudna, PhD, winner of the 2020 Vanderbilt Prize in Biomedical Science, will deliver the next web-based Discovery Lecture on Thursday, July 22.

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Preclinical study supports rigosertib as booster to immunotherapy treatment for melanoma

Jul. 1, 2021—A team of Vanderbilt researchers have shown in a preclinical study that the investigational drug rigosertib could be a potential booster treatment to elicit response to immunotherapies among melanoma patients.

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Drug allergy labels in medical records power searches for gene-drug associations

Jun. 17, 2021—  by Paul Govern A meta-analysis published in 1998 in the Journal of the American Medical Association estimated that, leaving aside overdoses and cases of drug abuse, 2.2 million patients admitted to U.S. hospitals in 1994 (6.7% of the total) were either admitted due to a serious adverse drug reaction or had a serious ADR...

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