A new view of a cholesterol carrier
Feb. 7, 2023—Vanderbilt researchers developed a novel method to measure small RNAs carried by HDL and demonstrated that these molecules circulate in greater concentrations than previously believed and are likely to contribute to communication between immune cells.
Who’s who in the respiratory landscape
Nov. 15, 2021—A metatranscriptomics method developed by Vanderbilt researchers simultaneously characterizes viruses, microbiome and host response in nasal swabs, opening opportunities to explore molecular interactions directly in clinical samples.
Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription
Sep. 30, 2021—Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.
Study finds that regulatory protein prevents signaling that triggers cell death
May. 6, 2021—A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.
Microbial RNA and rheumatoid arthritis
Jan. 11, 2021—Small RNAs — short stretches of genetic material — from microbes may be playing a role in rheumatoid arthritis and other autoimmune diseases.
Cellular antiviral defenses
Jul. 23, 2020—A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.
Cellular factor helps package flu genome
Mar. 23, 2020—New insights on influenza genome packaging could guide strategies for interfering with the virus’s life cycle and ability to cause infection.
Pua lands NIH Director’s New Innovator Award
Oct. 1, 2019—Heather Pua, MD, PhD, one of 60 investigators to receive the 2019 NIH Director’s New Innovator Award, will explore a novel type of cell signaling by RNAs in allergic airway inflammation.
VUMC investigators receive Keck Foundation award for novel atherosclerosis research
Aug. 26, 2019—A team of researchers has received a $1 million grant from the W.M. Keck Foundation to explore a novel model of atherosclerosis development.
Probing H. pylori cancer protein
Feb. 14, 2019—Understanding how a bacterial protein that influences the risk of stomach cancer is produced could guide new strategies for treatment.
RNA processing and antiviral immunity
Dec. 13, 2018—John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.
Studying cellular deliveries
Oct. 25, 2018—Vanderbilt researchers have characterized the functional transfer of long RNAs between colorectal cancer cells — a form of cell-cell communication that may contribute to cancer aggressiveness.